PMID- 29163114
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 11
DP  - 2017
TI  - Interaction between BDNF Polymorphism and Physical Activity on Inhibitory 
      Performance in the Elderly without Cognitive Impairment.
PG  - 541
LID - 10.3389/fnhum.2017.00541 [doi]
LID - 541
AB  - Background: In the elderly, physical activity (PA) enhances cognitive 
      performances, increases brain plasticity and improves brain health. The 
      neurotrophic hypothesis is that the release of brain-derived neurotrophic factor 
      (BDNF), which is implicated in brain plasticity and cognition, is triggered by PA 
      because motoneurons secrete BDNF into the bloodstream during exercise. Individual 
      differences in cognitive performance may be explained by individual differences 
      in genetic predisposition. A single nucleotide polymorphism on the BDNF gene, 
      BDNFVal66Met, affects activity-dependent BDNF secretion. This study investigated 
      the influence of the BDNFVal66Met polymorphism on the relationship between PA and 
      controlled inhibition performance in older adults. Methods: A total of 114 
      healthy elderly volunteers (mean age = 71.53 years old) were evaluated. 
      Participants were genotyped for the BDNFVal66Met polymorphism. We evaluated 
      inhibitory performance using choice reaction times (RT) and error rates from a 
      Simon-like task and estimated their PA using two self-reported questionnaires. We 
      established four groups according to PA level (active vs. inactive) and 
      BDNFVal66Met genotype (Met carriers vs. Val-homozygous). The results were 
      analyzed using ANOVA and ANCOVA, including age, gender and body mass index as 
      covariates. Results: The BDNFVal66Met polymorphism interacted with PA on 
      controlled inhibition performance. More specifically, inactive Val-homozygous 
      participants exhibited a lower inhibition performance than active Val homozygotes 
      and inactive Met carriers; the former had a higher error rate without differences 
      in RT. Conclusion: Differences between individuals on inhibitory performance may 
      be partially understood by the interaction between genetic influence in BDNF 
      secretion and PA level. The results of this study clearly support the 
      neurotrophic hypothesis that BDNF synthesis is an important mechanism underlying 
      the influence of physical activity on brain structure and functions.
FAU - Canivet, Anne
AU  - Canivet A
AD  - Universite de Poitiers, Centre de Recherches sur la Cognition et l'Apprentissage, 
      CNRS UMR 7295, Poitiers, France.
FAU - Albinet, Cedric T
AU  - Albinet CT
AD  - Universite de Poitiers, Centre de Recherches sur la Cognition et l'Apprentissage, 
      CNRS UMR 7295, Poitiers, France.
AD  - Laboratoire Sciences de la Cognition, Technologie, Ergonomie (SCoTE), Universite 
      de Toulouse, INU Champollion, Albi, France.
FAU - Rodriguez-Ballesteros, Montserrat
AU  - Rodriguez-Ballesteros M
AD  - Laboratoire CiMoTheMA - EA 3808, CHU de Poitiers, Universite de Poitiers, Groupe 
      Genetique des Maladies Rares, Poitiers, France.
FAU - Chicherio, Christian
AU  - Chicherio C
AD  - Neuropsychology Unit, Neurology Clinic, Department of Clinical Neurosciences, 
      Geneva University Hospitals, Geneva, Switzerland.
AD  - Center for Interdisciplinary Study of Gerontology and Vulnerability, University 
      of Geneva, Geneva, Switzerland.
FAU - Fagot, Delphine
AU  - Fagot D
AD  - Center for Interdisciplinary Study of Gerontology and Vulnerability, University 
      of Geneva, Geneva, Switzerland.
FAU - Andre, Nathalie
AU  - Andre N
AD  - Universite de Poitiers, Centre de Recherches sur la Cognition et l'Apprentissage, 
      CNRS UMR 7295, Poitiers, France.
FAU - Audiffren, Michel
AU  - Audiffren M
AD  - Universite de Poitiers, Centre de Recherches sur la Cognition et l'Apprentissage, 
      CNRS UMR 7295, Poitiers, France.
AD  - Maison des Sciences de l'Homme et de la Societe, CNRS USR 3565, Universite de 
      Poitiers, Poitiers, France.
LA  - eng
PT  - Journal Article
DEP - 20171107
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC5681928
OTO - NOTNLM
OT  - BDNF gene
OT  - aging
OT  - controlled inhibition
OT  - executive functions
OT  - genetic polymorphism
OT  - physical activity
OT  - reaction time
EDAT- 2017/11/23 06:00
MHDA- 2017/11/23 06:01
PMCR- 2017/01/01
CRDT- 2017/11/23 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2017/11/23 06:00 [entrez]
PHST- 2017/11/23 06:00 [pubmed]
PHST- 2017/11/23 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2017.00541 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2017 Nov 7;11:541. doi: 10.3389/fnhum.2017.00541. eCollection 
      2017.