PMID- 29163787
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 52
DP  - 2017 Oct 27
TI  - Neural crest derived progenitor cells contribute to tumor stroma and 
      aggressiveness in stage 4/M neuroblastoma.
PG  - 89775-89792
LID - 10.18632/oncotarget.21128 [doi]
AB  - Pediatric tumors arise upon oncogenic transformation of stem/progenitor cells 
      during embryonic development. Given this scenario, the existence of 
      non-tumorigenic stem cells included within the aberrant tumoral niche, with a 
      potential role in tumor biology, is an intriguing and unstudied possibility. 
      Here, we describe the presence and function of non-tumorigenic neural 
      crest-derived progenitor cells in aggressive neuroblastoma (NB) tumors. These 
      cells differentiate into neural crest typical mesectodermal derivatives, giving 
      rise to tumor stroma and promoting proliferation and tumor aggressiveness. 
      Furthermore, an analysis of gene expression profiles in stage 4/M NB revealed a 
      neural crest stem cell (NCSC) gene signature that was associated to stromal 
      phenotype and high probability of relapse. Thus, this NCSC gene expression 
      signature could be used in prognosis to improve stratification of stage 4/M NB 
      tumors. Our results might facilitate the design of new therapies by targeting 
      NCSCs and their contribution to tumor stroma.
FAU - Linares-Clemente, Pedro
AU  - Linares-Clemente P
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
FAU - Aguilar-Morante, Diana
AU  - Aguilar-Morante D
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
FAU - Rodriguez-Prieto, Ismael
AU  - Rodriguez-Prieto I
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
FAU - Ramirez, Gema
AU  - Ramirez G
AD  - Departamento de Oncologia Pediatrica, Hospital Universitario Virgen del Rocio, 
      Sevilla, Spain.
FAU - de Torres, Carmen
AU  - de Torres C
AD  - Departamento de Oncologia, Hospital Sant Joan de Deu, Barcelona, Spain.
FAU - Santamaria, Vicente
AU  - Santamaria V
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
AD  - Departamento de Oncologia Pediatrica, Hospital Universitario Virgen del Rocio, 
      Sevilla, Spain.
FAU - Pascual-Vaca, Diego
AU  - Pascual-Vaca D
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
AD  - Departamento de Anatomia Patologica, Hospital Universitario Virgen del Rocio, 
      Sevilla, Spain.
FAU - Colmenero-Repiso, Ana
AU  - Colmenero-Repiso A
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
FAU - Vega, Francisco M
AU  - Vega FM
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
FAU - Mora, Jaume
AU  - Mora J
AD  - Departamento de Oncologia, Hospital Sant Joan de Deu, Barcelona, Spain.
FAU - Cabello, Rosa
AU  - Cabello R
AD  - Departamento de Cirugia Pediatrica, Hospital Universitario Virgen del Rocio, 
      Sevilla, Spain.
FAU - Marquez, Catalina
AU  - Marquez C
AD  - Departamento de Oncologia Pediatrica, Hospital Universitario Virgen del Rocio, 
      Sevilla, Spain.
FAU - Rivas, Eloy
AU  - Rivas E
AD  - Departamento de Anatomia Patologica, Hospital Universitario Virgen del Rocio, 
      Sevilla, Spain.
FAU - Pardal, Ricardo
AU  - Pardal R
AD  - Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiologia Medica y 
      Biofisica, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 
      Sevilla, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170921
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5685708
OTO - NOTNLM
OT  - angiogenesis
OT  - neural crest-derived progenitors
OT  - neuroblastoma
OT  - smooth muscle actin (SMA)
OT  - tumor stroma
COIS- CONFLICTS OF INTEREST The authors state no potential conflicts of interest.
EDAT- 2017/11/23 06:00
MHDA- 2017/11/23 06:01
PMCR- 2017/10/27
CRDT- 2017/11/23 06:00
PHST- 2016/11/04 00:00 [received]
PHST- 2017/09/04 00:00 [accepted]
PHST- 2017/11/23 06:00 [entrez]
PHST- 2017/11/23 06:00 [pubmed]
PHST- 2017/11/23 06:01 [medline]
PHST- 2017/10/27 00:00 [pmc-release]
AID - 21128 [pii]
AID - 10.18632/oncotarget.21128 [doi]
PST - epublish
SO  - Oncotarget. 2017 Sep 21;8(52):89775-89792. doi: 10.18632/oncotarget.21128. 
      eCollection 2017 Oct 27.