PMID- 29164307
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20181113
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 38
IP  - 5
DP  - 2018 May
TI  - Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum 
      biomarkers in knee osteoarthritis: a cross-sectional study.
PG  - 821-830
LID - 10.1007/s00296-017-3887-y [doi]
AB  - Biochemical markers reflecting joint remodeling in osteoarthritis (OA) are a 
      promising diagnostic tool. The aim of this study was to investigate serum levels 
      of candidate biomarkers in subjects with and without knee OA and assess their 
      correlation with clinical parameters and knee structural damage. 56 patients with 
      primary knee OA and 31 healthy controls participated in this study. Patients were 
      separated into two groups: isolated knee OA and generalized OA. Clinical 
      parameters were obtained by validated self-reported questionnaires and a visual 
      analogue scale. Serum levels of cartilage oligomeric protein (COMP), matrix 
      metalloproteinase-3 (MMP-3), and Coll2-1 were quantified by enzyme-linked 
      immunosorbent assay. Knee structural damage was determined by plain X-ray and 
      1.5 T magnetic resonance imaging (MRI), using Kellgren-Lawrence (KL) grading 
      scale and Whole-Organ Magnetic Resonance Imaging Score (WORMS), respectively. 
      Compared to controls, patients had significantly higher median serum COMP (985 
      vs. 625 ng/ml; p < 0.001) and MMP-3 (36.85 vs. 22.10 ng/ml; p = 0.003) levels. 
      Patients with radiographic evidence of KLII/III knee OA had greater median COMP 
      levels than KLI patients (1095 vs. 720 ng/ml; p = 0.001). In the generalized OA 
      group, mean MMP-3 levels were higher than in the isolated knee OA group (30.40 
      vs. 55.13 ng/ml; p < 0.001). COMP correlated positively with WORMS (r 
      (s) = 0.454, p < 0.001) and MMP-3 (r (s) = 0.337, p = 0.003). Cut-off values for 
      serum COMP and MMP-3 were determined. We observed higher serum COMP and MMP-3 
      levels in knee OA patients compared to controls. COMP may reflect knee structural 
      damage, while MMP-3-OA "generalization".
FAU - Georgiev, Tsvetoslav
AU  - Georgiev T
AUID- ORCID: 0000-0002-1652-4648
AD  - Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical Faculty, 
      Medical University of Sofia, Sofia, Bulgaria. tsetso@medfaculty.org.
FAU - Ivanova, Mariana
AU  - Ivanova M
AD  - Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical Faculty, 
      Medical University of Sofia, Sofia, Bulgaria.
FAU - Kopchev, Aleksandar
AU  - Kopchev A
AD  - Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical Faculty, 
      Medical University of Sofia, Sofia, Bulgaria.
FAU - Velikova, Tsvetelina
AU  - Velikova T
AD  - Laboratory of Clinical Immunology, University Hospital "Lozenets", Medical 
      Faculty, Sofia University, Sofia, Bulgaria.
FAU - Miloshov, Asen
AU  - Miloshov A
AD  - Radiology Department, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
FAU - Kurteva, Ekaterina
AU  - Kurteva E
AD  - Laboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Medical 
      Faculty, Medical University of Sofia, Sofia, Bulgaria.
FAU - Yuzeir, Kalina
AU  - Yuzeir K
AD  - Laboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Medical 
      Faculty, Medical University of Sofia, Sofia, Bulgaria.
FAU - Penkov, Marin
AU  - Penkov M
AD  - Radiology Department, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
FAU - Kabakchieva, Plamena
AU  - Kabakchieva P
AD  - Clinic of Endocrinology, University Hospital "Aleksandrovska", Medical Faculty, 
      Medical University of Sofia, Sofia, Bulgaria.
FAU - Rashkov, Rasho
AU  - Rashkov R
AD  - Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical Faculty, 
      Medical University of Sofia, Sofia, Bulgaria.
FAU - Stoilov, Rumen
AU  - Stoilov R
AD  - Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical Faculty, 
      Medical University of Sofia, Sofia, Bulgaria.
LA  - eng
GR  - Project "Young Investigator" No 353/2015, contract No 22-D/2015/Medical 
      University Sofia/
PT  - Journal Article
DEP - 20171121
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Biomarkers)
RN  - 0 (COMP protein, human)
RN  - 0 (Cartilage Oligomeric Matrix Protein)
RN  - 0 (Collagen Type II)
RN  - 0 (Peptide Fragments)
RN  - 0 (collagen type II (108-116))
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Cartilage Oligomeric Matrix Protein/*blood
MH  - Case-Control Studies
MH  - Collagen Type II/*blood
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Knee Joint/*metabolism/physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*blood/diagnostic imaging/physiopathology
MH  - Peptide Fragments/*blood
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Self Report
MH  - Up-Regulation
OTO - NOTNLM
OT  - Biomarkers
OT  - Knee
OT  - Magnetic resonance imaging
OT  - Osteoarthritis
OT  - Radiography
EDAT- 2017/11/23 06:00
MHDA- 2018/09/25 06:00
CRDT- 2017/11/23 06:00
PHST- 2017/09/16 00:00 [received]
PHST- 2017/11/19 00:00 [accepted]
PHST- 2017/11/23 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2017/11/23 06:00 [entrez]
AID - 10.1007/s00296-017-3887-y [pii]
AID - 10.1007/s00296-017-3887-y [doi]
PST - ppublish
SO  - Rheumatol Int. 2018 May;38(5):821-830. doi: 10.1007/s00296-017-3887-y. Epub 2017 
      Nov 21.