PMID- 29164505
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 12
IP  - 5
DP  - 2018 Oct
TI  - Network-level dysconnectivity in patients with nasopharyngeal carcinoma (NPC) 
      early post-radiotherapy: longitudinal resting state fMRI study.
PG  - 1279-1289
LID - 10.1007/s11682-017-9801-0 [doi]
AB  - In this study, we seek to longitudinally investigate the network-level functional 
      connectivity (FC) alternations and its association with irradiation dose and 
      cognition changes in the early stage post radiotherapy (RT) in nasopharyngeal 
      carcinoma (NPC) patients. We performed independent component analysis (ICA) of 
      resting state blood oxygen level-dependent functional magnetic resonance imaging 
      (BOLD-fMRI) from 39 newly diagnosed NPC patients before receiving treatment 
      (baseline), and 3 months post-RT. the default mode network (DMN), salience 
      network (SN), and executive control network (ECN) were extracted with 
      well-validated software (GIFT). Inter-network connectivity was assessed using the 
      functional network connectivity (FNC) toolbox. The inter- and intra-network FC 
      was compared between time points, and the z value of FC alternation was 
      correlated with the RT dose value and cognitive changes. Compared with baseline, 
      the FC of the left anterior cingulate cortex (ACC) within the DMN, and the right 
      insular within the SN, significantly reduced 3 months post-RT, with greater 
      effects at higher doses in the right insular. Bilateral ECN FC was also 
      significantly lower 3 months post-RT compared to the baseline. Chemotherapy was 
      not associated with inter- and intra- network FC change. We found intra- and 
      inter-network FC disruption in NPC patients 3 months post-RT, with the right 
      insular showing a dose-dependent effect. Thus, this network-level FC may serve as 
      a potential biomarker of the RT-induced brain functional impairments, and provide 
      valuable targets for further functional recovery treatment.
FAU - Qiu, Yingwei
AU  - Qiu Y
AD  - Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou Medical University, Guangzhou, 510150, People's Republic of 
      China. qiuyw1201@gmail.com.
FAU - Guo, Zheng
AU  - Guo Z
AD  - Department of Oncology, The First Affiliated Hospital of Ganzhou Medical 
      University, Ganzhou, People's Republic of China.
FAU - Han, Lujun
AU  - Han L
AD  - Department of Medical Imaging Centre, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen 
      University Cancer Center, Guangzhou, People's Republic of China.
FAU - Yang, Yadi
AU  - Yang Y
AD  - Department of Medical Imaging Centre, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen 
      University Cancer Center, Guangzhou, People's Republic of China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Medical Imaging Centre, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen 
      University Cancer Center, Guangzhou, People's Republic of China.
FAU - Liu, Shiliang
AU  - Liu S
AD  - Department of Radiation Oncology, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen 
      University Cancer Center, Guangzhou, People's Republic of China.
FAU - Lv, Xiaofei
AU  - Lv X
AUID- ORCID: 0000-0002-1712-630X
AD  - Department of Medical Imaging Centre, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen 
      University Cancer Center, Guangzhou, People's Republic of China. 
      lvxf@sysucc.org.cn.
LA  - eng
GR  - 81401399/Natural Scientific Foundation of China/
GR  - 81201084 and 81560283/Natural Scientific Foundation of China/
GR  - 20151BAB205049/Natural Scientific Foundation of Jiangxi Province/
GR  - 15ykpy35/Fundamental Research Funds for the Central Universities/
GR  - B2014162/Medical Scientific Research Foundation of Guangdong Province/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
RN  - 0 (Antineoplastic Agents)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Antineoplastic Agents/therapeutic use
MH  - Brain/diagnostic imaging/*physiopathology/*radiation effects
MH  - Brain Mapping
MH  - Cerebrovascular Circulation
MH  - Cognition/radiation effects
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Carcinoma/diagnostic 
      imaging/*physiopathology/psychology/*radiotherapy
MH  - Nasopharyngeal Neoplasms/diagnostic 
      imaging/*physiopathology/psychology/*radiotherapy
MH  - Neural Pathways/diagnostic imaging/physiopathology/radiation effects
MH  - Oxygen/blood
MH  - Prospective Studies
MH  - Radiation Dosage
MH  - Rest
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Functional connectivity
OT  - Nasopharyngeal carcinoma
OT  - Network
OT  - Radiotherapy
OT  - Resting-state functional magnetic resonance imaging
EDAT- 2017/11/23 06:00
MHDA- 2019/04/02 06:00
CRDT- 2017/11/23 06:00
PHST- 2017/11/23 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2017/11/23 06:00 [entrez]
AID - 10.1007/s11682-017-9801-0 [pii]
AID - 10.1007/s11682-017-9801-0 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2018 Oct;12(5):1279-1289. doi: 10.1007/s11682-017-9801-0.