PMID- 29165142
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20220409
IS  - 1347-4715 (Electronic)
IS  - 1342-078X (Print)
IS  - 1342-078X (Linking)
VI  - 22
IP  - 1
DP  - 2017 Apr 4
TI  - The effect of exercise intensity on brain derived neurotrophic factor and memory 
      in adolescents.
PG  - 27
LID - 10.1186/s12199-017-0643-6 [doi]
LID - 27
AB  - BACKGROUND: Brain derived neurotrophic factor (BDNF) seems to serve as an 
      important regulatory mechanism in the growth and development of neurons in many 
      areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to 
      neurogenesis and regulation of the BDNF gene and is involved in the growth and 
      differentiation of neurons.Cortisol is released in response to stimuli such as 
      psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. 
      The purpose of this study was thus to examine the effects of varying intensities 
      of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and 
      memory of adolescents. METHODS: Forty male students with no history of physical 
      illness from the middle school by participated in this study. Participants were 
      randomly assigned to low, moderate, or high intensity treadmill exercise group, 
      or a stretching (control) group. Exercise was performed 4 times per week for 
      12 weeks. Body composition, brain derived neurotrophic factor levels, 
      insulin-like growth factor 1 levels, cortisol levels, and working memory were 
      assessed. RESULTS: The high intensity exercise group showed a significant 
      increase in brain derived neurotrophic factor at rest, concentration level of 
      insulin-like growth factor 1, cortisol, and working memory. For resting brain 
      derived neurotrophic factor, the high intensity exercise group showed a more 
      significant increase compared to the low intensity aerobic and stretching groups. 
      The change in the working memory significantly increased for the high intensity 
      exercise group compared to the low intensity aerobic group, moderate intensity 
      exercise group, and stretching group. CONCLUSIONS: In adolescents, whose brains 
      are still developing, aerobic exercise of moderate to high intensity levels seems 
      to have a positive effect on levels of serum brain derived neurotrophic factor at 
      rest and on cognitive functioning. TRIAL REGISTRATION: EHPM-D-16-00107R2 . ICMJE. 
      12 July 2016.
FAU - Jeon, Yong Kyun
AU  - Jeon YK
AD  - Department of Physical Education, Dankook University, Yongin, Republic of Korea.
FAU - Ha, Chang Ho
AU  - Ha CH
AD  - Department Human Performance and Leisure Studies, North Carolina A&T State 
      University, 1601 E. Market Street, Greensboro, NC, 27411, USA. 
      changhoha00@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170404
PL  - Japan
TA  - Environ Health Prev Med
JT  - Environmental health and preventive medicine
JID - 9609642
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IGF1 protein, human)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Exercise
MH  - Exercise Test
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - *Memory
MH  - Republic of Korea
PMC - PMC5664787
OTO - NOTNLM
OT  - BDNF
OT  - Exercise intensity
OT  - Memory
EDAT- 2017/11/23 06:00
MHDA- 2018/06/19 06:00
PMCR- 2017/04/04
CRDT- 2017/11/23 06:00
PHST- 2017/01/18 00:00 [received]
PHST- 2017/02/01 00:00 [accepted]
PHST- 2017/11/23 06:00 [entrez]
PHST- 2017/11/23 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/04/04 00:00 [pmc-release]
AID - 10.1186/s12199-017-0643-6 [pii]
AID - 643 [pii]
AID - 10.1186/s12199-017-0643-6 [doi]
PST - epublish
SO  - Environ Health Prev Med. 2017 Apr 4;22(1):27. doi: 10.1186/s12199-017-0643-6.