PMID- 29165313
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20220409
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 9
IP  - 11
DP  - 2017 Nov 20
TI  - T-cell differentiation and CD56+ levels in polypoidal choroidal vasculopathy and 
      neovascular age-related macular degeneration.
PG  - 2436-2452
LID - 10.18632/aging.101329 [doi]
AB  - Polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular 
      degeneration (AMD) are prevalent age-related diseases characterized by exudative 
      changes in the macula. Although they share anatomical and clinical similarities, 
      they are also distinctly characterized by their own features, e.g. vascular 
      abnormalities in PCV and drusen-mediated progression in neovascular AMD. PCV 
      remains etiologically uncharacterized, and ongoing discussion is whether PCV and 
      neovascular AMD share the same etiology or constitute two substantially different 
      diseases. In this study, we investigated T-cell differentiation and aging profile 
      in human patients with PCV, patients with neovascular AMD, and age-matched 
      healthy control individuals. Fresh venous blood was prepared for flow cytometry 
      to investigate CD4(+) and CD8(+) T-cell differentiation (naive, central memory, 
      effector memory, effector memory CD45ra(+)), loss of differentiation markers CD27 
      and CD28, and expression of aging marker CD56. Patients with PCV were similar to 
      the healthy controls in all aspects. In patients with neovascular AMD we found 
      significantly accelerated T-cell differentiation (more CD28(-)CD27(-) cells) and 
      aging (more CD56(+) cells) in the CD8(+) T-cell compartment. These findings 
      suggest that PCV and neovascular AMD are etiologically different in terms of T 
      cell immunity, and that neovascular AMD is associated with T-cell 
      immunosenescence.
FAU - Subhi, Yousif
AU  - Subhi Y
AD  - Clinical Eye Research Division, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Nielsen, Marie Krogh
AU  - Nielsen MK
AD  - Clinical Eye Research Division, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Molbech, Christopher Rue
AU  - Molbech CR
AD  - Clinical Eye Research Division, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Oishi, Akio
AU  - Oishi A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Singh, Amardeep
AU  - Singh A
AD  - Clinical Eye Research Division, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Department of Ophthalmology, Skane University Hospital Malmo-Lund, Lund, Sweden.
FAU - Nissen, Mogens Holst
AU  - Nissen MH
AD  - Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, 
      Denmark.
AD  - Eye Research Unit, Department of Immunology and Microbiology, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Sorensen, Torben Lykke
AU  - Sorensen TL
AD  - Clinical Eye Research Division, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, 
      Denmark.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Biomarkers)
RN  - 0 (CD28 Antigens)
RN  - 0 (CD56 Antigen)
RN  - 0 (NCAM1 protein, human)
RN  - 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - CD28 Antigens/blood
MH  - CD4-Positive T-Lymphocytes/*immunology/metabolism
MH  - CD56 Antigen/*blood
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism
MH  - Case-Control Studies
MH  - *Cell Differentiation
MH  - *Cellular Senescence
MH  - Choroidal Neovascularization/blood/*immunology/pathology
MH  - Female
MH  - Humans
MH  - Immunosenescence
MH  - Macular Degeneration/blood/*immunology/pathology
MH  - Male
MH  - *Neovascularization, Pathologic
MH  - Prospective Studies
MH  - Tumor Necrosis Factor Receptor Superfamily, Member 7/blood
PMC - PMC5723695
OTO - NOTNLM
OT  - T-cells
OT  - age-related macular degeneration
OT  - immunosenescence
OT  - polypoidal choroidal vasculopathy
COIS- CONFLICTS OF INTEREST Author Y.S. has previously received travel grant for 
      conferences from Novartis and Bayer (not in relation to this work). Author M.K.N. 
      has previously received travel grant for conference from Novartis (not in 
      relation to this work). Author C.R.M. has previously received a travel grant from 
      Bayer (not in relation to this work). Author A.S. has previously received travel 
      grant for conferences from Novartis and speaker honoraria from Bayer (not in 
      relation to this work). Author A.O. has received grants from Novartis and Alcon, 
      and speaker honoraria from Novartis and Bayer (not in relation to this work). 
      Authors M.H.S. and T.L.S. declare that no potential conflicts of interests exist 
      in relation to this work.
EDAT- 2017/11/23 06:00
MHDA- 2018/02/06 06:00
PMCR- 2017/11/01
CRDT- 2017/11/23 06:00
PHST- 2017/09/15 00:00 [received]
PHST- 2017/11/11 00:00 [accepted]
PHST- 2017/11/23 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2017/11/23 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 101329 [pii]
AID - 10.18632/aging.101329 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2017 Nov 20;9(11):2436-2452. doi: 10.18632/aging.101329.