PMID- 29167796 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220310 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 4 DP - 2017 TI - Tinnitus after Simultaneous and Sequential Bilateral Cochlear Implantation. PG - 65 LID - 10.3389/fsurg.2017.00065 [doi] LID - 65 AB - IMPORTANCE: There is an ongoing global discussion on whether or not bilateral cochlear implantation should be standard care for bilateral deafness. Contrary to unilateral cochlear implantation, however, little is known about the effect of bilateral cochlear implantation on tinnitus. OBJECTIVE: To investigate tinnitus outcomes 1 year after bilateral cochlear implantation. Secondarily, to compare tinnitus outcomes between simultaneous and sequential bilateral cochlear implantation and to investigate long-term follow-up (3 years). STUDY DESIGN: This study is a secondary analysis as part of a multicenter randomized controlled trial. METHODS: Thirty-eight postlingually deafened adults were included in the original trial, in which the presence of tinnitus was not an inclusion criterion. All participants received cochlear implants (CIs) because of profound hearing loss. Nineteen participants received bilateral CIs simultaneously and 19 participants received bilateral CIs sequentially with an inter-implant interval of 2 years. The prevalence and severity of tinnitus before and after simultaneous and sequential bilateral cochlear implantation were measured preoperatively and each year after implantation with the Tinnitus Handicap Inventory (THI) and Tinnitus Questionnaire (TQ). RESULTS: The prevalence of preoperative tinnitus was 42% (16/38). One year after bilateral implantation, there was a median difference of -8 (inter-quartile range (IQR): -28 to 4) in THI score and -9 (IQR: -17 to -9) in TQ score in the participants with preoperative tinnitus. Induction of tinnitus occurred in five participants, all in the simultaneous group, in the year after bilateral implantation. Although the preoperative and also the postoperative median THI and TQ scores were higher in the simultaneous group, the median difference scores were equal in both groups. In the simultaneous group, tinnitus scores fluctuated in the 3 years after implantation. In the sequential group, four patients had an additional benefit of the second CI: a total suppression of tinnitus compared with their unilateral situation. CONCLUSION: While bilateral cochlear implantation can have a positive effect on preoperative tinnitus complaints, the induction of (temporary or permanent) tinnitus was also reported. CLINICAL TRIAL REGISTRATION: Dutch Trial Register NTR1722. FAU - Ramakers, Geerte G J AU - Ramakers GGJ AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Kraaijenga, Veronique J C AU - Kraaijenga VJC AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Smulders, Yvette E AU - Smulders YE AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. FAU - van Zon, Alice AU - van Zon A AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Stegeman, Inge AU - Stegeman I AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Stokroos, Robert J AU - Stokroos RJ AD - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands. FAU - Free, Rolien H AU - Free RH AD - Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, Netherlands. AD - Graduate School of Medical Sciences, Research School of Behavioural and Cognitive Neurosciences, University Medical Center Groningen, Groningen, Netherlands. FAU - Frijns, Johan H M AU - Frijns JHM AD - Department of Otorhinolaryngology, Head and Neck Surgery, Leiden University Medical Center, Leiden, Netherlands. AD - Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, Netherlands. FAU - Huinck, Wendy J AU - Huinck WJ AD - Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, Nijmegen, Netherlands. AD - Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands. FAU - Van Zanten, Gijsbert A AU - Van Zanten GA AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Grolman, Wilko AU - Grolman W AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. AD - Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. LA - eng PT - Journal Article DEP - 20171113 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC5682406 OTO - NOTNLM OT - Tinnitus Handicap Inventory OT - Tinnitus Questionnaire OT - bilateral cochlear implantation OT - cochlear implantation OT - sequential OT - simultaneous OT - tinnitus EDAT- 2017/11/24 06:00 MHDA- 2017/11/24 06:01 PMCR- 2017/11/13 CRDT- 2017/11/24 06:00 PHST- 2017/08/25 00:00 [received] PHST- 2017/10/31 00:00 [accepted] PHST- 2017/11/24 06:00 [entrez] PHST- 2017/11/24 06:00 [pubmed] PHST- 2017/11/24 06:01 [medline] PHST- 2017/11/13 00:00 [pmc-release] AID - 10.3389/fsurg.2017.00065 [doi] PST - epublish SO - Front Surg. 2017 Nov 13;4:65. doi: 10.3389/fsurg.2017.00065. eCollection 2017.