PMID- 29167990
OWN - NLM
STAT- MEDLINE
DCOM- 20180404
LR  - 20181113
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 472
IP  - 2
DP  - 2018 Feb
TI  - Histologic analysis has a prognostical value in colorectal biopsies assessed for 
      suspicion of graft-versus-host disease.
PG  - 213-220
LID - 10.1007/s00428-017-2272-2 [doi]
AB  - Gastrointestinal (GI) graft-versus-host-disease (GVHD) is a common and severe 
      complication of allogeneic hematopoietic stem cell transplantation, but clinical 
      and histological features are unspecific. The aim of this study was to correlate 
      the histological GI GVHD grade with the clinical outcomes. In a retrospective 
      study of 112 patients with clinically suspected GI GVHD, colonic biopsies were 
      reviewed by three pathologists without knowledge of the corresponding clinical 
      data and classified in four scores, according to the NIH Consensus Project 
      recommendations: no GVHD, possible, probable, and unequivocal GVHD. At the end of 
      the study, the histological and clinical data were confronted with the following 
      results: clinical diagnosis of GI GVHD was established for 70 patients (62.5%) 
      and histological scores correlated well with the clinical diagnosis (p < 0.001) 
      and particularly with the prognosis (p < 0.05).When severe lesions were observed, 
      the 1 year overall survival declined to 9%. None of the features reported in the 
      literature to support GVHD diagnosis, eosinophil count, endocrine cells 
      aggregate, immunohistochemical analysis (cytomegalovirus, CD123, chromogranin), 
      did not help us for diagnosis. So routine histopathology alone without 
      immunohistochemistry is a strong and reproducible tool to diagnose GI GVHD with 
      the help of clinical and biological information, and most importantly, 
      histological grading proved to be a powerful prognostic value.
FAU - Sauvestre, Fanny
AU  - Sauvestre F
AUID- ORCID: 0000-0001-6759-0648
AD  - Department of Pathology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Avenue de Magellan, 33604, Pessac, France. fanny.sauvestre@u-bordeaux.fr.
FAU - Belleannee, Genevieve
AU  - Belleannee G
AD  - Department of Pathology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Avenue de Magellan, 33604, Pessac, France.
FAU - Breal, Claire
AU  - Breal C
AD  - Department of Hematology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Pessac, France.
FAU - Mohr, Catherine
AU  - Mohr C
AD  - Department of Hematology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Pessac, France.
FAU - Fong, Harold IpKan
AU  - Fong HI
AD  - Department of Pathology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Avenue de Magellan, 33604, Pessac, France.
FAU - Cossin, Sebastien
AU  - Cossin S
AD  - ISPED, Population Health, University of Bordeaux, Bordeaux, France.
FAU - Tabrizi, Reza
AU  - Tabrizi R
AD  - Department of Hematology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Pessac, France.
FAU - Milpied, Noel
AU  - Milpied N
AD  - Department of Hematology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Pessac, France.
FAU - Vigouroux, Stephane
AU  - Vigouroux S
AD  - Department of Hematology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Pessac, France.
FAU - Goussot, Jean-Francois
AU  - Goussot JF
AD  - Department of Pathology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Avenue de Magellan, 33604, Pessac, France.
FAU - Marty, Marion
AU  - Marty M
AD  - Department of Pathology, University Hospital of Bordeaux, Haut-Leveque Hospital, 
      Avenue de Magellan, 33604, Pessac, France.
LA  - eng
PT  - Journal Article
DEP - 20171122
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Colon/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/*diagnosis/etiology/mortality/*pathology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Prognosis
MH  - Rectum/*pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Young Adult
OTO - NOTNLM
OT  - Apoptosis
OT  - Colon
OT  - Graft-versus host disease
OT  - Mycophenolate mofetil
OT  - Stem cell transplantation
EDAT- 2017/11/24 06:00
MHDA- 2018/04/05 06:00
CRDT- 2017/11/24 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/11/14 00:00 [accepted]
PHST- 2017/10/21 00:00 [revised]
PHST- 2017/11/24 06:00 [pubmed]
PHST- 2018/04/05 06:00 [medline]
PHST- 2017/11/24 06:00 [entrez]
AID - 10.1007/s00428-017-2272-2 [pii]
AID - 10.1007/s00428-017-2272-2 [doi]
PST - ppublish
SO  - Virchows Arch. 2018 Feb;472(2):213-220. doi: 10.1007/s00428-017-2272-2. Epub 2017 
      Nov 22.