PMID- 29167994
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20190529
IS  - 1433-0350 (Electronic)
IS  - 0256-7040 (Linking)
VI  - 34
IP  - 1
DP  - 2018 Jan
TI  - Congenital Zika virus infection: a neuropathological review.
PG  - 95-99
LID - 10.1007/s00381-017-3651-3 [doi]
AB  - BACKGROUND: A relationship between Zika virus (ZikV) infection in pregnancy and 
      the occurrence of microcephaly was established during the Zika outbreak in Brazil 
      (2015-2016). Neuropathological findings in congenital Zika syndrome helped to 
      understand its pathogenetic mechanisms. RESULTS: The most relevant postmortem 
      findings in the central nervous system (CNS) of fetuses and neonates infected 
      with ZikV early in gestation are microcephaly with ex-vacuo ventriculomegaly and 
      large head circumference associated with obstructive hydrocephalus due to severe 
      midbrain and aqueduct distortion. Babies with severe brain lesions are born with 
      arthrogryposis. Histologically, there is extensive destruction of the hemispheric 
      parenchyma, calcifications, various disturbances of neuronal migration, reactive 
      gliosis, microglial hyperplasia and occasional perivascular cuffs of lymphocytes, 
      also in the meninges. Hypoplastic lesions secondary to the lack of descending 
      nerve fibers include small basis pontis, pyramids and spinal corticospinal 
      tracts. Cerebellar hypoplasia is also common. Severe nerve motor nerve cell loss 
      is observed in the anterior horn of the spinal cord. CONCLUSION: A spectrum of 
      neuropathological changes, from severe microcephaly to obstructive hydrocephalus 
      was observed. The severity of the lesions is directly related to the gestational 
      age, the most severe occurring when the mother is infected in the first 
      trimester. Infection of progenitor cells at the germinal matrix was demonstrated. 
      The lack of spinal motor neurons is responsible for fetal acynesia and consequent 
      arthrogryposis.
FAU - Chimelli, L
AU  - Chimelli L
AD  - Laboratory of Neuropathology, State Institute of Brain Paulo Niemeyer and Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
FAU - Avvad-Portari, E
AU  - Avvad-Portari E
AUID- ORCID: 0000-0003-2372-0898
AD  - Fernandes Figueira Institute-Oswaldo Cruz Foundation (Fiocruz) and State 
      University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil. bethavvad@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171122
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for 
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
MH  - Adult
MH  - Brain/pathology
MH  - Brazil
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Microcephaly/etiology/pathology
MH  - Nervous System/pathology
MH  - Pregnancy
MH  - Zika Virus Infection/*congenital/*pathology
OTO - NOTNLM
OT  - Calcifications
OT  - Congenital Zika virus infection
OT  - Microcephaly
OT  - Migration disturbances
OT  - Neuropathology
OT  - Ventriculomegaly
EDAT- 2017/11/24 06:00
MHDA- 2019/05/30 06:00
CRDT- 2017/11/24 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2017/10/27 00:00 [accepted]
PHST- 2017/11/24 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
PHST- 2017/11/24 06:00 [entrez]
AID - 10.1007/s00381-017-3651-3 [pii]
AID - 10.1007/s00381-017-3651-3 [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2018 Jan;34(1):95-99. doi: 10.1007/s00381-017-3651-3. Epub 2017 
      Nov 22.