PMID- 29170704
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1939-795X (Print)
IS  - 1939-795X (Electronic)
IS  - 1939-795X (Linking)
VI  - 10
IP  - 7
DP  - 2017
TI  - A Pre-Exercise Dose of Melatonin Can Alter Substrate Use During Exercise.
PG  - 1029-1037
AB  - Notwithstanding the lack of exercise research, several reviews have championed 
      the use of melatonin to combat metabolic syndrome. Therefore, this study compared 
      substrate utilization during a 30-minute (min) graded exercise protocol following 
      the ingestion of either 6 mg melatonin (M) or a placebo (P). Participants (12 
      women, 12 men) performed stages 1-5 of the Naughton graded exercise protocol (6 
      min per stage). The protocol was repeated 4 times (2x M, 2x P) at the same time 
      of day with one week separating each session. Expired gases were monitored, VO(2) 
      and respiratory exchange ratio (RER) output was provided every 30s. Total, 
      carbohydrate (CHO), and fat energy expenditures were obtained from the RER values 
      using the formulae of Lusk. The VO(2) at which CHO accounted for 50% of the total 
      caloric expenditure was calculated by a VO(2): RER regression line. Additionally, 
      the energy derived was calculated by multiplying VO(2) and the respective energy 
      expenditures. Then, the total, CHO, and fat energies consumed during the 30 min 
      of exercise were determined by calculating the area under the kJ/min: time curve 
      using the trapezoid rule. The final data for the two similar trials were averaged 
      and a paired-T test was used for statistical comparison. The average VO(2) for 
      50% CHO usage was significantly lower following M (0.84 +/- 0.54 l.min(-1)) than 
      after P (1.21 +/- 0.52 l.min(-1)). Also, average CHO kJ for M (627 +/- 284) was 
      significantly (p < 0.004) greater than P (504 +/- 228), and accounted for a 
      significantly greater contribution of total kJ consumed (M = 68% +/-15 vs. P = 61% 
      +/- 18). Ingestion of melatonin 30 min prior to an aerobic exercise bout elevates 
      CHO use during exercise.
FAU - Trionfante, Cardyl P
AU  - Trionfante CP
AD  - School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
FAU - Davis, Greggory R
AU  - Davis GR
AD  - School of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA, USA.
FAU - Farney, Tyler M
AU  - Farney TM
AD  - School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
FAU - Miskowiec, Ryan W
AU  - Miskowiec RW
AD  - School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
FAU - Nelson, Arnold G
AU  - Nelson AG
AD  - School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
LA  - eng
PT  - Journal Article
DEP - 20171101
PL  - United States
TA  - Int J Exerc Sci
JT  - International journal of exercise science
JID - 101513127
PMC - PMC5685071
OTO - NOTNLM
OT  - Carbohydrate metabolism
OT  - caloric expenditure
OT  - cross-over point
OT  - metabolic syndrome
EDAT- 2017/11/25 06:00
MHDA- 2017/11/25 06:01
PMCR- 2017/11/01
CRDT- 2017/11/25 06:00
PHST- 2017/11/25 06:00 [entrez]
PHST- 2017/11/25 06:00 [pubmed]
PHST- 2017/11/25 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - ijes_10_7_1029 [pii]
PST - epublish
SO  - Int J Exerc Sci. 2017 Nov 1;10(7):1029-1037. eCollection 2017.