PMID- 29171209
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1738-5520 (Print)
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Linking)
VI  - 47
IP  - 6
DP  - 2017 Nov
TI  - Relationship between Pulmonary Artery Stiffness and Functional Capacity in 
      Patients with Heart Failure with Reduced Ejection Fraction.
PG  - 929-938
LID - 10.4070/kcj.2017.0081 [doi]
AB  - BACKGROUND AND OBJECTIVES: Functional capacity varies significantly among 
      patients with heart failure with reduced ejection fraction (HFrEF), and it 
      remains unclear why functional capacity is severely compromised in some patients 
      with HFrEF while it is preserved in others. In this study, we aimed to evaluate 
      the role of pulmonary artery stiffness (PAS) in the functional status of patients 
      with HFrEF. METHODS: A total of 46 heart failure (HF) patients without overt 
      pulmonary hypertension or right HF and 52 controls were enrolled in the study. 
      PAS was assessed on parasternal short-axis view using pulsed-wave Doppler 
      recording of pulmonary flow one centimeter distal to the pulmonic valve annulus 
      at a speed of 100 mm/sec. PAS was calculated according to the following formula: 
      the ratio of maximum flow velocity shift of pulmonary flow to pulmonary 
      acceleration time. RESULTS: PAS was significantly increased in the HFrEF group 
      compared to the control group (10.53+/-2.40 vs. 7.41+/-1.32, p<0.001). In sub-group 
      analysis of patients with HFrEF, PAS was significantly associated with the 
      functional class of the patients. HFrEF patients with poor New York Heart 
      Association (NYHA) functional capacity had higher PAS compared those with good 
      functional capacity. In multivariate regression analysis, NYHA class was 
      independently correlated with PAS. CONCLUSION: PAS is associated with functional 
      status and should be taken into consideration as an underlying pathophysiological 
      mechanism of dyspnea in patients with HFrEF.
CI  - Copyright (c) 2017. The Korean Society of Cardiology
FAU - Yildirim, Erkan
AU  - Yildirim E
AUID- ORCID: 0000-0001-5343-6156
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey. 
      dr_erkanyildirim@yahoo.com.tr.
FAU - Celik, Murat
AU  - Celik M
AUID- ORCID: 0000-0002-3149-0853
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Yuksel, Uygar Cagdas
AU  - Yuksel UC
AUID- ORCID: 0000-0003-1531-6967
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Gungor, Mutlu
AU  - Gungor M
AUID- ORCID: 0000-0002-3318-2133
AD  - Department of Cardiology, Memorial Sisli Hospital, Istanbul, Turkey.
FAU - Bugan, Baris
AU  - Bugan B
AUID- ORCID: 0000-0002-7210-9537
AD  - Department of Cardiology, Corlu State Hospital, Tekirdag, Turkey.
FAU - Dogan, Deniz
AU  - Dogan D
AUID- ORCID: 0000-0003-2596-3113
AD  - Department of Thoracic Medicine, Gulhane Training and Research Hospital, Ankara, 
      Turkey.
FAU - Gokoglan, Yalcin
AU  - Gokoglan Y
AUID- ORCID: 0000-0002-8929-6850
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Kabul, Hasan Kutsi
AU  - Kabul HK
AUID- ORCID: 0000-0002-5258-4269
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Gormel, Suat
AU  - Gormel S
AUID- ORCID: 0000-0002-6621-551X
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Yasar, Salim
AU  - Yasar S
AUID- ORCID: 0000-0003-2290-0184
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Koklu, Mustafa
AU  - Koklu M
AUID- ORCID: 0000-0002-4581-8514
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
FAU - Barcin, Cem
AU  - Barcin C
AUID- ORCID: 0000-0003-4092-8463
AD  - Department of Cardiology, Gulhane Training and Research Hospital, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20171106
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
PMC - PMC5711685
OTO - NOTNLM
OT  - Ejection fraction
OT  - Heart failure
OT  - Pulmonary artery
OT  - Stroke volume
OT  - Vascular stiffness
COIS- The authors have no financial conflicts of interest.
EDAT- 2017/11/25 06:00
MHDA- 2017/11/25 06:01
PMCR- 2017/11/01
CRDT- 2017/11/25 06:00
PHST- 2017/04/08 00:00 [received]
PHST- 2017/06/07 00:00 [revised]
PHST- 2017/06/21 00:00 [accepted]
PHST- 2017/11/25 06:00 [pubmed]
PHST- 2017/11/25 06:01 [medline]
PHST- 2017/11/25 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 47.e329 [pii]
AID - 10.4070/kcj.2017.0081 [doi]
PST - ppublish
SO  - Korean Circ J. 2017 Nov;47(6):929-938. doi: 10.4070/kcj.2017.0081. Epub 2017 Nov 
      6.