PMID- 29171354 OWN - NLM STAT- MEDLINE DCOM- 20171215 LR - 20181202 IS - 1532-2750 (Electronic) IS - 1098-612X (Linking) VI - 19 IP - 12 DP - 2017 Dec TI - Haematology and coagulation profiles in cats with congenital portosystemic shunts. PG - 1290-1296 LID - 10.1177/1098612X17693490 [doi] AB - Objectives The objectives of this study were, first, to report the haematological parameters and coagulation times for cats with a congenital portosystemic shunt (CPSS) and the influence of surgical shunt attenuation on these parameters; and, second, to identify any association between prolongation in coagulation profiles and incidence of perioperative haemorrhage. Methods This was a retrospective clinical study using client-owned cats with a CPSS. Signalment, shunt type (extra- or intrahepatic), degree of shunt attenuation (complete or partial), haematological parameters, prothrombin time (PT) and activated partial thromboplastin time (aPTT) test results, and occurrence of any perioperative clinical bleeding complications were recorded for cats undergoing surgical treatment of a CPSS at the Royal Veterinary College, UK, between 1994 and 2011. Results Forty-two cats were included. Thirty-six (85.7%) had an extrahepatic CPSS and six (14.3%) had an intrahepatic CPSS. Preoperatively, mean cell volume (MCV) and mean cell haemoglobin (MCH) were below the reference interval (RI) in 32 (76.2%) and 31 (73.8%) cats, respectively. Red blood cell count and mean cell haemoglobin concentration (MCHC) were above the RI in 10 (23.8%) and eight (19.1%) cats, respectively. Postoperatively, there were significant increases in haematocrit ( P = 0.044), MCV ( P = 0.008) and MCH ( P = 0.002). Despite the significant increase in MCV postoperatively, the median MCV postoperatively was below the RI, indicating persistence of microcytosis. Preoperatively, PT was above the upper RI in 14 cats (87.5%), and aPTT was above the upper RI in 11 cats (68.8%). No cat demonstrated a perioperative clinical bleeding complication. Conclusions and relevance Cats with a CPSS are likely to present with a microcytosis, but rarely present with anaemia, leukocytosis or thrombocytopenia. Surgical attenuation of the CPSS results in a significant increase in the HCT and MCV. Coagulation profiles in cats with a CPSS are likely to be prolonged, irrespective of shunt type, but do not appear to be associated with an increased risk of clinical bleeding. FAU - Tzounos, Caitlin E AU - Tzounos CE AD - 1 Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, UK. FAU - Tivers, Michael S AU - Tivers MS AD - 2 School of Veterinary Sciences, University of Bristol, Bristol, UK. FAU - Adamantos, Sophie E AU - Adamantos SE AD - 3 Langford Vets, Small Animal Referral Hospital, University of Bristol, Bristol, UK. FAU - English, Kate AU - English K AD - 4 Department of Pathology and Pathogen Biology, Royal Veterinary College, Hatfield, UK. FAU - Rees, Alan L AU - Rees AL AD - 1 Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, UK. FAU - Lipscomb, Vicky J AU - Lipscomb VJ AD - 1 Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, UK. LA - eng PT - Journal Article DEP - 20170201 PL - England TA - J Feline Med Surg JT - Journal of feline medicine and surgery JID - 100897329 SB - IM MH - Animals MH - Cat Diseases/blood/congenital/*surgery MH - Cats MH - Erythrocyte Count/veterinary MH - Female MH - Hypertension, Portal/blood/surgery/veterinary MH - Male MH - Partial Thromboplastin Time/veterinary MH - Portal System/*abnormalities/surgery MH - Prothrombin Time/veterinary MH - Retrospective Studies EDAT- 2017/11/25 06:00 MHDA- 2017/12/16 06:00 CRDT- 2017/11/25 06:00 PHST- 2017/11/25 06:00 [entrez] PHST- 2017/11/25 06:00 [pubmed] PHST- 2017/12/16 06:00 [medline] AID - 10.1177/1098612X17693490 [doi] PST - ppublish SO - J Feline Med Surg. 2017 Dec;19(12):1290-1296. doi: 10.1177/1098612X17693490. Epub 2017 Feb 1.