PMID- 29171440 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200929 IS - 1673-5374 (Print) IS - 1876-7958 (Electronic) IS - 1673-5374 (Linking) VI - 12 IP - 10 DP - 2017 Oct TI - Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration. PG - 1733-1741 LID - 10.4103/1673-5374.217353 [doi] AB - Neurotoxicity induced by stress, radiation, chemicals, or metabolic diseases, is commonly associated with excitotoxicity, oxidative stress, and neuroinflammation. The pathological process of neurotoxicity induces neuronal death, interrupts synaptic plasticity in the brain, and is similar to that of diverse neurodegenerative diseases. Animal models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative processes. Specifically, brain-derived neurotropic factor (BDNF) and gamma-aminobutyric acid (GABA)-ergic transmission are related to both neurodegeneration and neuroregeneration. This review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission, their underlying mechanisms, and the relationship between BDNF and GABA in neurodegeneration and neuroregeneration. This review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease. FAU - Kim, Jinwook AU - Kim J AD - Departments of Veterinary Anatomy and Veterinary Toxicology, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, Gwangju, South Korea. FAU - Lee, Sueun AU - Lee S AD - Departments of Veterinary Anatomy and Veterinary Toxicology, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, Gwangju, South Korea. FAU - Kang, Sohi AU - Kang S AD - Departments of Veterinary Anatomy and Veterinary Toxicology, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, Gwangju, South Korea. FAU - Kim, Sung-Ho AU - Kim SH AD - Departments of Veterinary Anatomy and Veterinary Toxicology, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, Gwangju, South Korea. FAU - Kim, Jong-Choon AU - Kim JC AD - Departments of Veterinary Anatomy and Veterinary Toxicology, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, Gwangju, South Korea. FAU - Yang, Miyoung AU - Yang M AD - Department of Anatomy, School of Medicine and Institute for Environmental Science, Wonkwang University, Jeonbuk, South Korea. FAU - Moon, Changjong AU - Moon C AD - Departments of Veterinary Anatomy and Veterinary Toxicology, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, Gwangju, South Korea. LA - eng PT - Journal Article PT - Review PL - India TA - Neural Regen Res JT - Neural regeneration research JID - 101316351 PMC - PMC5696856 OTO - NOTNLM OT - brain-derived neurotropic factor OT - gamma-aminobutyric acid-ergic transmission OT - neural regeneration OT - neurodegenerative diseases OT - neurotoxicity COIS- None declared EDAT- 2017/11/25 06:00 MHDA- 2017/11/25 06:01 PMCR- 2017/10/01 CRDT- 2017/11/25 06:00 PHST- 2017/11/25 06:00 [entrez] PHST- 2017/11/25 06:00 [pubmed] PHST- 2017/11/25 06:01 [medline] PHST- 2017/10/01 00:00 [pmc-release] AID - NeuralRegenRes_2017_12_10_1733_217353 [pii] AID - NRR-12-1733 [pii] AID - 10.4103/1673-5374.217353 [doi] PST - ppublish SO - Neural Regen Res. 2017 Oct;12(10):1733-1741. doi: 10.4103/1673-5374.217353.