PMID- 29171467
OWN - NLM
STAT- MEDLINE
DCOM- 20180327
LR  - 20221207
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 89
IP  - 10
DP  - 2017
TI  - [Microcirculatory parameters in compensated and decompensated type 2 diabetes 
      mellitus].
PG  - 28-35
LID - 10.17116/terarkh2017891028-35 [doi]
AB  - AIM: To reveal the features of microcirculatory parameters in compensated and 
      decompensated type 2 diabetes mellitus (T2DM). SUBJECTS AND METHODS: A total of 
      196 patients with T2DM were examined and divided into 2 groups: 1) 52 patients 
      (40.4% of men) aged 52.8+/-8.7 years with compensated T2DM (glycated hemoglobin 
      (HbA1small es, Cyrillic), 6.3+/-0.5%); 2) 68 patients (38.2% of men) aged 52.8+/-8.1 years with 
      decompensated T2DM (HbA1small es, Cyrillic, 9.4+/-1.7%). Both patient groups had concomitant 
      hypertension (its prevalence, degree, stage of hypertension were comparable). A 
      control group consisted of 76 volunteers (40.8% of men) aged 52.2+/-8.7 years with 
      normal carbohydrate metabolism and without signs of cardiovascular disease 
      (HbA1small es, Cyrillic, 5.3+/-0.49%). Capillary blood flow in the finger nail-fold area was 
      investigated in all the participants. A digital optical capillaroscope with 
      image-processing software was used to obtain quantitative blood microcirculatory 
      parameters. The diameters of arterial and venous capillary segments were 
      measured, by calculating the remodeling rate. The degree of capillary tortuosity, 
      network density, and polymorphism and the size of the perivascular zone (PZ) were 
      estimated. Blood rheological properties and capillary blood flow velocity were 
      also investigated. RESULTS: The decompensated T2DM group compared to the 
      compensated T2DM group was found to have a narrowing of the arterial capillary 
      segment diameter (8.4+/-2.0 microm; p=0.009) and an increase in remodeling rates 
      (1.47+/-0.22; p=0.000). The tendency of the PZ size to be larger in patients with 
      decompensated T2DM compared to those with compensated T2DM (p=0.080) and the 
      increase in this indicator compared to the control group (p=0.001) reflect the 
      presence of edema syndrome in Group 2, as laboratory confirmed by a statistically 
      significantly elevated sodium level (p=0.000; p=0.006). The enlarged venous 
      capillary segment demonstrates involvement of the venous component in 
      microcirculatory disorders in T2DM. The reduction in the density of the capillary 
      network and the increase in capillary tortuosity and polymorphism, which were 
      also observed in the patients of both groups versus the control group, are 
      referred to as disorders that are characteristic of T2DM. CONCLUSION: In 
      decompensated T2DM, capillary bed structural and functional changes are found as 
      a narrowing of the arterial capillary segment, an increase in the rate of 
      remodeling, and enlargement of the PZ. Digital capillaroscopy opens up new 
      possibilities for assessing the magnitude of changes in the microcirculatory 
      system in DM and can simultaneously evaluate the efficiency of treatment, by 
      monitoring the status of the microvasculature.
FAU - Suchkova, O V
AU  - Suchkova OV
AD  - Research Clinical Center, OAO "RZhD", Moscow, Russia.
FAU - Gurfinkel, Yu I
AU  - Gurfinkel YI
AD  - Research Clinical Center, OAO "RZhD", Moscow, Russia.
FAU - Sasonko, M L
AU  - Sasonko ML
AD  - Research Clinical Center, OAO "RZhD", Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Parametry mikrotsirkuliatsii pri kompensirovannom i dekompensirovannom sakharnom 
      diabete 2-go tipa.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Comorbidity
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology/physiopathology
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Hemodynamics
MH  - Humans
MH  - *Hypertension/epidemiology/physiopathology
MH  - Male
MH  - *Microcirculation
MH  - Microscopic Angioscopy/*methods
MH  - *Microvessels/diagnostic imaging/physiopathology
MH  - Middle Aged
MH  - Patient Acuity
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Vascular Remodeling
OTO - NOTNLM
OT  - blood microcirculation
OT  - capillary tortuosity
OT  - digital nail-fold capillaroscopy
OT  - glycated hemoglobin
OT  - narrowed arterial capillary segment
OT  - remodeling rate
OT  - type 2 diabetes mellitus
EDAT- 2017/11/25 06:00
MHDA- 2018/03/28 06:00
CRDT- 2017/11/25 06:00
PHST- 2017/11/25 06:00 [entrez]
PHST- 2017/11/25 06:00 [pubmed]
PHST- 2018/03/28 06:00 [medline]
AID - 10.17116/terarkh2017891028-35 [doi]
PST - ppublish
SO  - Ter Arkh. 2017;89(10):28-35. doi: 10.17116/terarkh2017891028-35.