PMID- 29172743
OWN - NLM
STAT- MEDLINE
DCOM- 20180620
LR  - 20181202
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 40
IP  - 1
DP  - 2018
TI  - Impact of hyperhomocysteinemia on insulin resistance in patients with H-type 
      hypertension.
PG  - 28-31
LID - 10.1080/10641963.2017.1288738 [doi]
AB  - BACKGROUND: Hypertension (HT) and hyperhomocysteinemia (HHcy) had been considered 
      influential factors of insulin resistance. H-type HT occurred as HHcy associated 
      with HT. The impact of HHcy on insulin resistance in H-type HT patients remains 
      to be estimated. The interacted effects of HHcy and HT on insulin resistance are 
      still unclear. METHODS: A total of 790 patients were recruited and classified 
      into four groups according to their blood pressure and plasma Hcy level, i.e., 
      control group (C group), HHcy group (HHcy subjects without HT), HT group (HT 
      subjects without HHcy), and H group (subjects with H-type HT). The relationship 
      between HHcy and insulin resistance, as estimated using the HOMA-IR, was analyzed 
      and related to blood pressure. RESULTS: HOMA-IR values were significantly higher 
      in the HHcy group than the C group (2.97 (2.23-4.01) versus 2.54 (1.87-3.58), P ＜ 
      0.01). H-type HT patients showed more severe insulin resistance than those who 
      only got HT (3.58 (2.59-4.85) versus 2.96 (1.90-3.49)，P ＜ 0.01). Moreover, 
      HOMA-IR values were positively correlated with Hcy levels (r = 0.26, P ＜ 0.01). 
      After correcting for possible risking factors, a linear regression relationship 
      between insulin resistance and HHcy was found (beta = 0.158, P ＜ 0.01). HHcy was 
      interacted with HT on the exacerbation of insulin resistance in H-type HT 
      patients (beta = 0.501, P ＜ 0.01). CONCLUSIONS: HHcy obviously exacerbate insulin 
      resistance, especially in H-type HT patients. HHcy and HT have a multiplicative 
      effect on metabolic dysfunction, which may help to interpret why these patients 
      are suffering a high risk of cardiovascular disease and stroke.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - a Department of Endocrinology, Beijing Chao-Yang Hospital , Capital Medical 
      University , Beijing , P. R. of China.
FAU - Wang, Guang
AU  - Wang G
AD  - a Department of Endocrinology, Beijing Chao-Yang Hospital , Capital Medical 
      University , Beijing , P. R. of China.
FAU - Liu, Jia
AU  - Liu J
AD  - a Department of Endocrinology, Beijing Chao-Yang Hospital , Capital Medical 
      University , Beijing , P. R. of China.
FAU - Xu, Yuan
AU  - Xu Y
AD  - a Department of Endocrinology, Beijing Chao-Yang Hospital , Capital Medical 
      University , Beijing , P. R. of China.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - *Blood Pressure
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/complications/*physiopathology
MH  - Hypertension/blood/complications/*physiopathology
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - hyperhomocysteinemia
OT  - hypertension
OT  - insulin resistance
OT  - metabolic disease
EDAT- 2017/11/28 06:00
MHDA- 2018/06/21 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - 10.1080/10641963.2017.1288738 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2018;40(1):28-31. doi: 10.1080/10641963.2017.1288738. Epub 
      2017 Nov 27.