PMID- 29172835
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20181004
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 40
IP  - 5
DP  - 2018
TI  - Prevalence of hyperhomocysteinemia and its associated factors in patients with 
      primary hypertension in Chinese urban communities: A cross-sectional study from 
      Nanjing.
PG  - 495-500
LID - 10.1080/10641963.2017.1403621 [doi]
AB  - OBJECTIVE: This study aimed to investigate the prevalence of hyperhomocysteinemia 
      (Hhcy) and its major determinants in Chinese urban population with new-onset 
      hypertension. METHODS: A total of 574 adults (404 men and 170 women) with newly 
      diagnosed primary hypertension were recruited from seven communities in Nanjing, 
      China. Data on lifestyle factors, such as physical activities, current smoking 
      and drinking status, dietary habits, and familial factors were collected in 
      interviews, and laboratory examinations were performed by well-trained personnel. 
      Potential factors related to the prevalence of Hhcy in this population were 
      analyzed using a logistic regression model. RESULTS: Of the 574 participants, 421 
      (73.3%) were diagnosed with Hhcy whereas the remainder were only hypertensive. 
      The study highlighted a number of factors that were significantly correlated 
      (p < 0.001) with the prevalence of Hhcy. Subjects with Hhcy were more likely to 
      be male (odds ratio [OR] 3.007, 95% confidence interval [CI] 1.781-5.079), have a 
      smoking history (OR 1.052, 95% CI 1.031-1.074), older (OR 1.052, 95% CI 
      1.031-1.074), have an elevated Body Mass Index BMI (OR 1.160, 95% CI 1.080-1.246) 
      and higher levels of low density lipoprotein cholesterol (LDL-c) (OR 1.590, 95% 
      CI 1.226-2.063). Regular and adequate physical activity was associated with 
      normal homocysteine levels in both male and female groups (p < 0.05). For males 
      only, having a higher BMI, higher LDL-c or being older significantly (p < 0.05) 
      affected the chances of Hhcy. Whereas for females, lower levels of eGFR could be 
      related to Hhcy (p < 0.05). CONCLUSIONS: Our present study reported a high 
      prevalence of Hhcy in the Nanjing population with new-onset hypertension. 
      Associated factors like physical activity, gender, smoking history, age, BMI, and 
      LDL-c were important modifiers of plasma homocysteine concentration. Management 
      and intervention of the above associated factors should be implicated to improve 
      H type hypertension control.
FAU - Wang, Wei
AU  - Wang W
AD  - a Chronic Disease and Health Management Research Center, the Geriatrics Institute 
      of Jiangsu Province , Nanjing , China.
AD  - b Department of Cardiology , the Geriatrics Hospital of Jiangsu Province , 
      Nanjing , China.
FAU - Ji, Peng
AU  - Ji P
AD  - b Department of Cardiology , the Geriatrics Hospital of Jiangsu Province , 
      Nanjing , China.
FAU - Wang, Yi
AU  - Wang Y
AD  - b Department of Cardiology , the Geriatrics Hospital of Jiangsu Province , 
      Nanjing , China.
FAU - Guo, Hongmei
AU  - Guo H
AD  - b Department of Cardiology , the Geriatrics Hospital of Jiangsu Province , 
      Nanjing , China.
FAU - Bian, Rongwen
AU  - Bian R
AD  - a Chronic Disease and Health Management Research Center, the Geriatrics Institute 
      of Jiangsu Province , Nanjing , China.
FAU - Xu, Jiaren
AU  - Xu J
AD  - a Chronic Disease and Health Management Research Center, the Geriatrics Institute 
      of Jiangsu Province , Nanjing , China.
FAU - Xiong, Yaqing
AU  - Xiong Y
AD  - a Chronic Disease and Health Management Research Center, the Geriatrics Institute 
      of Jiangsu Province , Nanjing , China.
AD  - b Department of Cardiology , the Geriatrics Hospital of Jiangsu Province , 
      Nanjing , China.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Cholesterol, LDL/blood
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Essential Hypertension/*epidemiology/physiopathology
MH  - Exercise
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/*epidemiology/physiopathology
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Sex Factors
MH  - Smoking/epidemiology
MH  - Urban Population/statistics & numerical data
OTO - NOTNLM
OT  - Chinese urban community
OT  - H type hypertension
OT  - new-onset hypertension
EDAT- 2017/11/28 06:00
MHDA- 2018/09/27 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - 10.1080/10641963.2017.1403621 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2018;40(5):495-500. doi: 10.1080/10641963.2017.1403621. Epub 
      2017 Nov 27.