PMID- 29173495
OWN - NLM
STAT- MEDLINE
DCOM- 20171205
LR  - 20210803
IS  - 1388-2139 (Electronic)
IS  - 1383-5742 (Linking)
VI  - 774
DP  - 2017 Oct
TI  - Inflammation and the chemical carcinogen benzo[a]pyrene: Partners in crime.
PG  - 12-24
LID - S1383-5742(17)30053-4 [pii]
LID - 10.1016/j.mrrev.2017.08.003 [doi]
AB  - Exposure to benzo[a]pyrene (B[a]P) is known to play a role in lung carcinogenesis 
      and the underlying processes can be modified by the presence of inflammation. The 
      inflammatory process can for instance enhance the concentration of reactive 
      metabolites that bind to DNA and may also diminish DNA repair. Additionally, 
      during the inflammatory process mediators are released that create a 
      microenvironment which is suitable for further stimulation of cancer development. 
      Various transcriptional pathways are activated by inflammation, including 
      pathways that are mediated via nuclear factor kappa-light-chain-enhancer of 
      activated B cells (NF-kappaB), signal transducer and activator of transcription 3 
      (STAT-3), and hypoxia-inducible factor-1 (HIF-1). Crosstalk between these 
      pathways and the aryl hydrocarbon receptor (AhR) occurs at multiple levels and 
      thereby boosts B[a]P induced carcinogenesis. This review focuses on inflammatory 
      mediators, including cytokines, chemokines and extracellular enzymes that 
      modulate molecular events in B[a]P induced cancers.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Shi, Q
AU  - Shi Q
AD  - Department of Pharmacology & Toxicology, NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD, 
      Maastricht, The Netherlands.
FAU - Godschalk, R W L
AU  - Godschalk RWL
AD  - Department of Pharmacology & Toxicology, NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD, 
      Maastricht, The Netherlands.
FAU - van Schooten, F J
AU  - van Schooten FJ
AD  - Department of Pharmacology & Toxicology, NUTRIM School of Nutrition and 
      Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD, 
      Maastricht, The Netherlands; Departement of Pharmacology & Toxicology, NUTRIM 
      School for Nutrition and Translational Research in Metabolism, Maastricht 
      University, PO Box 616, 6200 MD, Maastricht, The Netherlands. Electronic address: 
      F.vanschooten@maastrichtuniversity.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170824
PL  - Netherlands
TA  - Mutat Res Rev Mutat Res
JT  - Mutation research. Reviews in mutation research
JID - 101632211
RN  - 0 (Carcinogens)
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Animals
MH  - Benzo(a)pyrene/*toxicity
MH  - Carcinogens/*toxicity
MH  - Humans
MH  - Inflammation/chemically induced/*complications
MH  - Neoplasms/*etiology/pathology
OTO - NOTNLM
OT  - Benzo[a]pyrene
OT  - Carcinogens
OT  - Cytochrom P450 1A1
OT  - Inflammation
OT  - Inflammatory mediators
EDAT- 2017/11/28 06:00
MHDA- 2017/12/06 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/08/02 00:00 [revised]
PHST- 2017/08/19 00:00 [accepted]
PHST- 2017/11/28 06:00 [entrez]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2017/12/06 06:00 [medline]
AID - S1383-5742(17)30053-4 [pii]
AID - 10.1016/j.mrrev.2017.08.003 [doi]
PST - ppublish
SO  - Mutat Res Rev Mutat Res. 2017 Oct;774:12-24. doi: 10.1016/j.mrrev.2017.08.003. 
      Epub 2017 Aug 24.