PMID- 29174061 OWN - NLM STAT- MEDLINE DCOM- 20180907 LR - 20200106 IS - 1873-474X (Electronic) IS - 0736-5748 (Linking) VI - 66 DP - 2018 May TI - Pathobiological expression of the brain-derived neurotrophic factor (BDNF) in cerebellar cortex of sudden fetal and infant death victims. PG - 9-17 LID - S0736-5748(17)30241-1 [pii] LID - 10.1016/j.ijdevneu.2017.11.003 [doi] AB - Brain-derived neurotrophic factor (BDNF), a neurotrophin of the central nervous system, is able to regulate neuronal differentiation and modulate synaptic plasticity, being particularly involved in the development of the cerebellar cortical structure. The main aim of this study was to delineate, by immunohistochemistry, the BDNF expression in human cerebellar cortex of victims of fetal and infant death. The study was performed on a total of 45 cases, aged between 25 gestational weeks and 6 postnatal months, including 29 victims of sudden fetal and infant death and 16 age-matched subjects who died of known causes (Controls). We observed, in sudden death groups compared with Controls, a significantly higher incidence of defective BDNF expression in granule layers of the cerebellar cortex, which was particularly evident in the posterior lobule, a region that participates in respiratory control. These results were related to maternal smoking, allowing to speculate that nicotine, in addition to the well-known damages, can exert adverse effects during cerebellar cortex development, in particular in hindering the BDNF expression in the posterior lobule. This implies modifications of synaptic transmission in the respiratory circuits, with obvious deleterious consequences on survival. CI - Copyright (c) 2017 ISDN. Published by Elsevier Ltd. All rights reserved. FAU - Lavezzi, Anna M AU - Lavezzi AM AD - "Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. Electronic address: anna.lavezzi@unimi.it. FAU - Ferrero, Stefano AU - Ferrero S AD - "Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy; Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. FAU - Lattuada, Debora AU - Lattuada D AD - "Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. FAU - Piscioli, Francesco AU - Piscioli F AD - Institute of Pathology, Hospital of Rovereto (Trento), Italy. FAU - Alfonsi, Graziella AU - Alfonsi G AD - "Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. FAU - Matturri, Luigi AU - Matturri L AD - "Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. LA - eng PT - Journal Article DEP - 20171123 PL - United States TA - Int J Dev Neurosci JT - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience JID - 8401784 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Glial Fibrillary Acidic Protein) RN - 0 (Membrane Glycoproteins) RN - EC 2.7.10.1 (Receptor, trkB) RN - EC 2.7.10.1 (tropomyosin-related kinase-B, human) SB - IM MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Case-Control Studies MH - Cerebellar Cortex/*metabolism/*pathology MH - Female MH - *Fetal Death MH - Fetus MH - Gestational Age MH - Glial Fibrillary Acidic Protein/metabolism MH - Humans MH - Infant MH - *Infant Death MH - Infant, Newborn MH - Male MH - Membrane Glycoproteins/metabolism MH - Neuroglia/metabolism/pathology MH - Neurons/metabolism/pathology MH - Pregnancy MH - Prenatal Exposure Delayed Effects/pathology MH - Receptor, trkB/metabolism MH - Smoking/adverse effects MH - Stillbirth OTO - NOTNLM OT - Brain-derived neutrophic factor (BDNF) OT - Central nerve system OT - Cerebellar cortex OT - Granule layers OT - Neuropathology OT - SIDS OT - SIUDS EDAT- 2017/11/28 06:00 MHDA- 2018/09/08 06:00 CRDT- 2017/11/28 06:00 PHST- 2017/08/15 00:00 [received] PHST- 2017/10/28 00:00 [revised] PHST- 2017/11/16 00:00 [accepted] PHST- 2017/11/28 06:00 [pubmed] PHST- 2018/09/08 06:00 [medline] PHST- 2017/11/28 06:00 [entrez] AID - S0736-5748(17)30241-1 [pii] AID - 10.1016/j.ijdevneu.2017.11.003 [doi] PST - ppublish SO - Int J Dev Neurosci. 2018 May;66:9-17. doi: 10.1016/j.ijdevneu.2017.11.003. Epub 2017 Nov 23.