PMID- 29174117
OWN - NLM
STAT- MEDLINE
DCOM- 20190620
LR  - 20220330
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 32
IP  - 2
DP  - 2018 Feb
TI  - RS 10767664 gene variant in Brain Derived Neurotrophic Factor (BDNF) affect 
      metabolic changes and insulin resistance after a standard hypocaloric diet.
PG  - 216-220
LID - S1056-8727(17)30417-8 [pii]
LID - 10.1016/j.jdiacomp.2017.10.005 [doi]
AB  - BACKGROUND: Role of BDNF variants on change in body weight and cardiovascular 
      risk factors after weight loss remains unclear in obese patients. OBJECTIVE: Our 
      aim was to analyze the effects of rs10767664 BDNF gene polymorphism on body 
      weight, cardiovascular risk factors and serum adipokine levels after a standard 
      hypocaloric diet in obese subjects. DESIGN: A Caucasian population of 80 obese 
      patients was analyzed before and after 3months on a standard hypocaloric diet. 
      RESULTS: Fifty patients (62.5%) had the genotype AA and 30 (37.5%) subjects had 
      the next genotypes; AT (25 patients, 31.3%) or TT (5 study subjects, 6.3%) 
      (second group). In non T allele carriers, the decreases in weight-3.4+/-2.9kg (T 
      allele group -1.7+/-2.0kg:p=0.01), BMI -1.5+/-0.2kg (T allele group 
      -1.2+/-0.5kg:p=0.02), fat mass-2.3+/-1.1kg (T allele group -1.7+/-0.9kg:p=0.009), waist 
      circumference-3.8+/-2.4cm (T allele group -2.1+/-3.1cm:p=0.008), triglycerides 
      -13.2+/-7.5mg/dl (T allele group +2.8+/-1.2mg/dl:p=0.02), insulin -2.1+/-1.9mUI/L (T 
      allele group -0.3+/-1.0mUI/L:p=0.01), HOMA-IR -0.9+/-0.4 (T allele group 
      -0.1+/-0.8:p=0.01) and leptin -10.1+/-9.5ng/dl (T allele group -3.1+/-0.2ng/dl:p=0.01) 
      were higher than T allele carriers. CONCLUSION: rs10767664 variant of BDNF gene 
      modify anthropometric and biochemical changes after weight loss with a 
      hypocaloric diet.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - de Luis, Daniel Antonio
AU  - de Luis DA
AD  - Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. 
      of Endocrinology and Nutrition, Hospital Clinico Universitario, University of 
      Valladolid, Valladolid, Spain. Electronic address: dluisro@saludcastillayleon.es.
FAU - Fernandez Ovalle, H
AU  - Fernandez Ovalle H
AD  - Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. 
      of Endocrinology and Nutrition, Hospital Clinico Universitario, University of 
      Valladolid, Valladolid, Spain.
FAU - Izaola, O
AU  - Izaola O
AD  - Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. 
      of Endocrinology and Nutrition, Hospital Clinico Universitario, University of 
      Valladolid, Valladolid, Spain.
FAU - Primo, D
AU  - Primo D
AD  - Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. 
      of Endocrinology and Nutrition, Hospital Clinico Universitario, University of 
      Valladolid, Valladolid, Spain.
FAU - Aller, Rocio
AU  - Aller R
AD  - Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. 
      of Endocrinology and Nutrition, Hospital Clinico Universitario, University of 
      Valladolid, Valladolid, Spain.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20171014
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Diet, Reducing/standards
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/*diet therapy/*genetics/*metabolism
MH  - *Polymorphism, Single Nucleotide
MH  - Reference Standards
MH  - Weight Loss/genetics
OTO - NOTNLM
OT  - BDNF
OT  - Hypocaloric diet
OT  - Insulin
OT  - Insulin resistance
OT  - rs10767664
EDAT- 2017/11/28 06:00
MHDA- 2019/06/21 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/03/22 00:00 [received]
PHST- 2017/10/10 00:00 [revised]
PHST- 2017/10/11 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2019/06/21 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - S1056-8727(17)30417-8 [pii]
AID - 10.1016/j.jdiacomp.2017.10.005 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2018 Feb;32(2):216-220. doi: 
      10.1016/j.jdiacomp.2017.10.005. Epub 2017 Oct 14.