PMID- 29174244
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20181202
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 69
IP  - 6
DP  - 2017 Nov-Dec
TI  - Left ventricular global longitudinal strain following revascularization in acute 
      ST elevation myocardial infarction - A comparison of primary angioplasty and 
      Streptokinase-based pharmacoinvasive strategy.
PG  - 695-699
LID - S0019-4832(17)30044-5 [pii]
LID - 10.1016/j.ihj.2017.04.010 [doi]
AB  - OBJECTIVE: Tenecteplase-based pharmacoinvasive percutaneous coronary intervention 
      (PCI) has been shown to yield outcomes comparable to primary PCI in the setting 
      of acute ST elevation myocardial infarction (STEMI). This study was designed to 
      compare the efficacy of pharmacoinvasive PCI following successful thrombolysis 
      with Streptokinase versus primary PCI in patients with STEMI. METHODOLOGY: We 
      conducted a prospective single center observational study in 120 patients with 
      STEMI who underwent primary PCI (n=60) and Streptokinase-based pharmacoinvasive 
      PCI (n=60). Patients with Killips class 3 or 4 at presentation, and those with 
      evidence of failed fibrinolysis were excluded. The primary outcome was LV 
      systolic function after angioplasty, as assessed by 2D global longitudinal strain 
      (GLS) using speckle tracking echocardiography (STE), as well as 2D LVEF using 
      Simpson's biplane method. RESULTS: LV systolic function after PCI was 
      significantly lower in the pharmacoinvasive arm as compared to the primary PCI 
      arm, both by 2D STE (GLS: -9% vs -11%; p=0.03) and 2D Simpson's biplane method 
      (LVEF: 40.7% vs 45.1%; p=0.02). TIMI flow in the culprit vessel prior to 
      angioplasty was better in the pharmacoinvasive arm indicating successful 
      thrombolysis, whereas post angioplasty flow was not different. There was no 
      in-hospital mortality in either group. There was a trend toward increased 
      incidence of acute kidney injury in the pharmacoinvasive arm. CONCLUSION: LV 
      systolic function is significantly better after primary angioplasty as compared 
      to pharmacoinvasive PCI following successful thrombolysis with Streptokinase.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Paul, Amal
AU  - Paul A
AD  - Department of Cardiology, Christian Medical College Vellore, Tamilnadu 632004, 
      India. Electronic address: look_lama@yahoo.co.in.
FAU - George, Paul V
AU  - George PV
AD  - Department of Cardiology, Christian Medical College Vellore, Tamilnadu 632004, 
      India. Electronic address: pvg@cmcvellore.ac.in.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20170509
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Fibrinolytic Agents)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - WGD229O42W (Tenecteplase)
SB  - IM
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Fibrinolytic Agents/therapeutic use
MH  - Follow-Up Studies
MH  - Heart Ventricles/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/diagnosis/*physiopathology/therapy
MH  - Tenecteplase
MH  - Thrombolytic Therapy/*methods
MH  - Tissue Plasminogen Activator/*therapeutic use
MH  - Ventricular Function, Left/*physiology
PMC - PMC5717277
OTO - NOTNLM
OT  - Global longitudinal strain (GLS)
OT  - Pharmacoinvasive PCI
OT  - Primary PCI
OT  - Streptokinase
EDAT- 2017/11/28 06:00
MHDA- 2018/07/17 06:00
PMCR- 2018/11/01
CRDT- 2017/11/28 06:00
PHST- 2017/01/22 00:00 [received]
PHST- 2017/04/09 00:00 [revised]
PHST- 2017/04/17 00:00 [accepted]
PHST- 2017/11/28 06:00 [entrez]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - S0019-4832(17)30044-5 [pii]
AID - 10.1016/j.ihj.2017.04.010 [doi]
PST - ppublish
SO  - Indian Heart J. 2017 Nov-Dec;69(6):695-699. doi: 10.1016/j.ihj.2017.04.010. Epub 
      2017 May 9.