PMID- 29174375
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20180806
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 213
DP  - 2018 Mar 1
TI  - Actinidia arguta extract attenuates inflammasome activation: Potential 
      involvement in NLRP3 ubiquitination.
PG  - 159-165
LID - S0378-8741(17)32623-5 [pii]
LID - 10.1016/j.jep.2017.11.023 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Actinidia arguta (A. arguta) has been widely used 
      in Asian countries as a traditional medicinal herb to treat inflammation-related 
      diseases, such as gastritis, bronchitis, and arthritis. AIM OF THE STUDY: The 
      inhibitory effect of A. arguta leaves' extract (AA) on inflammasome activation 
      was investigated to verify its traditional use in treating inflammation-related 
      diseases. MATERIALS AND METHODS: Bone marrow-derived macrophages (BMDMs) primed 
      by lipopolysaccharide (LPS) were activated by selective inflammasome stimulators, 
      and the effect of AA on inflammasome activation was investigated. A monosodium 
      urate crystal (MSU)-induced peritonitis mouse model was used to study the in vivo 
      efficacy of AA on inflammasome activation. RESULTS: In the in vitro study, AA 
      regulated NLRP3 ubiquitination and apoptosis-associated speck-like protein 
      containing a CARD (ASC) oligomerization, leading to the inhibition of NLRP3 
      inflammasome-mediated interleukin (IL)-1beta secretion. The inhibitory effect of AA 
      on inflammasome activation in vitro was further confirmed in vivo using an 
      MSU-induced peritonitis mouse model. CONCLUSION: AA provided scientific evidence, 
      substantiating the traditional claims for its use in the treatment of 
      inflammation and inflammation-mediated metabolic disorders, including gout.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Heo, Kang-Hyuck
AU  - Heo KH
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea.
FAU - Sun, Xiao
AU  - Sun X
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea.
FAU - Shim, Do-Wan
AU  - Shim DW
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea.
FAU - Kim, Myong-Ki
AU  - Kim MK
AD  - Department of Food Science and Engineering, Seowon University, Cheongju, Republic 
      of Korea.
FAU - Koppula, Sushruta
AU  - Koppula S
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, 268 Chungwon-daero, 
      Chungju, Republic of Korea.
FAU - Yu, Sang-Hyeun
AU  - Yu SH
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea.
FAU - Kim, Han-Bi
AU  - Kim HB
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea.
FAU - Kim, Tack-Joong
AU  - Kim TJ
AD  - Division of Biological Science and Technology, Institute of Biomaterials, Yonsei 
      University, Wonju, Republic of Korea.
FAU - Kang, Tae-Bong
AU  - Kang TB
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea; Department of Biotechnology, College of Biomedical & Health 
      Science, Research Institute of Inflammatory Diseases, Konkuk University, 268 
      Chungwon-daero, Chungju, Republic of Korea. Electronic address: 
      kangtbko@gmail.com.
FAU - Lee, Kwang-Ho
AU  - Lee KH
AD  - Department of Applied Life Science, Graduate School, Konkuk University, Chungju, 
      Republic of Korea; Department of Biotechnology, College of Biomedical & Health 
      Science, Research Institute of Inflammatory Diseases, Konkuk University, 268 
      Chungwon-daero, Chungju, Republic of Korea. Electronic address: 
      kwangho@kku.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20171121
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Plant Extracts)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - *Actinidia
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use
MH  - Caspase 1/metabolism
MH  - Cells, Cultured
MH  - Female
MH  - Inflammasomes/*metabolism
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophages/drug effects/metabolism
MH  - Mice, Inbred C57BL
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
MH  - Peritonitis/chemically induced/drug therapy/metabolism
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Plant Leaves
MH  - Ubiquitination
MH  - Uric Acid
OTO - NOTNLM
OT  - ASC
OT  - Actinidia arguta
OT  - Inflammasome
OT  - NLRP3
OT  - Peritonitis
OT  - Ubiquitination
EDAT- 2017/11/28 06:00
MHDA- 2018/08/07 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/07/11 00:00 [received]
PHST- 2017/11/07 00:00 [revised]
PHST- 2017/11/17 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - S0378-8741(17)32623-5 [pii]
AID - 10.1016/j.jep.2017.11.023 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2018 Mar 1;213:159-165. doi: 10.1016/j.jep.2017.11.023. Epub 
      2017 Nov 21.