PMID- 29174461
OWN - NLM
STAT- MEDLINE
DCOM- 20180221
LR  - 20180221
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1072
DP  - 2018 Jan 1
TI  - Multivariate optimization of solvent bar microextraction combined with HPLC-UV 
      for determination of trace amounts of vincristine in biological fluids.
PG  - 397-404
LID - S1570-0232(17)30794-8 [pii]
LID - 10.1016/j.jchromb.2017.10.054 [doi]
AB  - In the current work, an efficient method named solvent bar microextraction-high 
      performance liquid chromatography-UV detection (HPLC-UV) was developed for 
      preconcentration and determining the trace amount of vincristine (VCR) in 
      biological samples such as plasma and urine. Briefly, VCR was extracted from an 
      aqueous sample with pH 10.7 (donor phase) into 1-octanol as the supported liquid 
      membrane (SLM) which is inserted into the pores of the hollow fiber and followed 
      by back extraction into an aqueous receiving phase (pH=3.1). Studying the factors 
      affecting the extraction performance in order to achieve a high extraction 
      efficiency, requires the design of experiments (DOE) approach. In this regards, 
      diverse factors' effects including the pH value of donor and acceptor phases, 
      extraction time, extraction temperature, stirring rate and salt content of the 
      donor phase were considered. The optimum experimental condition was as following: 
      pH of the source phase, 10.7; pH of the receiving phase, 3.1; stirring rate, 
      1000rpm; extraction temperature, 51 degrees C; extraction time, 60min and 11.3% w/v NaCl 
      in the sample solution. Under the optimal; extraction condition, a favorable 
      preconcentration factor equal to 98.5 was achieved. The linearity range was 
      obtained in the domain of 0.05-5mgL(-1). The limits of detection and 
      quantification were 0.015 and 0.05mgL(-1). Within-day and between-day RSDs of the 
      proposed SBME method were 4.1% and 12.5%, respectively. Finally, the 
      applicability of the implemented SBME method was evaluated by the extraction and 
      quantification of VCR from biological samples such as urine and plasma and 
      satisfactory results were obtained.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Kiani, Mahsa
AU  - Kiani M
AD  - Active Pharmaceutical Ingredients Research Center (APIRC), Pharmaceutical 
      Sciences Research Center, Medicinal Chemistry Department, Faculty of 
      Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad 
      University, Tehran-Iran.
FAU - Qomi, Mahnaz
AU  - Qomi M
AD  - Active Pharmaceutical Ingredients Research Center (APIRC), Pharmaceutical 
      Sciences Research Center, Medicinal Chemistry Department, Faculty of 
      Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad 
      University, Tehran-Iran. Electronic address: Qomi@iaups.ac.ir.
FAU - Hashemian, Farshad
AU  - Hashemian F
AD  - Clinical Pharmacy Department, Pharmaceutical Sciences Research Center, 
      Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
FAU - Rajabi, Mehdi
AU  - Rajabi M
AD  - Clinical Pharmacy Department, Pharmaceutical Sciences Research Center, 
      Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20171029
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 5J49Q6B70F (Vincristine)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Humans
MH  - Limit of Detection
MH  - Linear Models
MH  - Liquid Phase Microextraction/*methods
MH  - Reproducibility of Results
MH  - Research Design
MH  - Vincristine/*analysis/isolation & purification
OTO - NOTNLM
OT  - Biological fluids
OT  - Design of experiment
OT  - Preconcentration
OT  - Solvent bar microextraction
OT  - Vincristine
EDAT- 2017/11/28 06:00
MHDA- 2018/02/22 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/04/28 00:00 [received]
PHST- 2017/09/25 00:00 [revised]
PHST- 2017/10/28 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/02/22 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - S1570-0232(17)30794-8 [pii]
AID - 10.1016/j.jchromb.2017.10.054 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:397-404. doi: 
      10.1016/j.jchromb.2017.10.054. Epub 2017 Oct 29.