PMID- 29174582
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 2531-0437 (Electronic)
IS  - 2531-0429 (Linking)
DP  - 2017 Nov 22
TI  - Macitentan in daily clinical practice: A single centre, 1-year experience.
LID - S2173-5115(17)30149-5 [pii]
LID - 10.1016/j.rppnen.2017.10.001 [doi]
AB  - The effectiveness and safety of macitentan, a dual endothelin-receptor antagonist 
      (ERA) approved for the treatment of pulmonary arterial hypertension (PAH), were 
      shown in an extensive clinical trial oriented towards morbidity and mortality 
      events. Our aim was to describe a single centre's experience of the utilization 
      of macitentan in patients with PAH in clinical practice settings. Thirteen 
      patients with different aetiologies and previous PAH treatments were studied. 
      After 12 months of macitentan treatment, 11 patients improved their functional 
      class (FC), all patients improved their 6-minute walk distance (6MWD) test, and 
      10 patients lowered their NT-proBNP plasma levels. Additionally, cardiac imaging 
      parameters were also improved. No cases resulted in hospitalization, septostomy, 
      transplant or death.
CI  - Copyright (c) 2017 Sociedade Portuguesa de Pneumologia. Published by Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Cadenas-Menendez, S
AU  - Cadenas-Menendez S
AD  - Pulmonology Service, Pulmonary Hypertension Unit, Complejo Asistencial 
      Universitario de Salamanca, Salamanca, Spain. Electronic address: 
      sercam.2007@gmail.com.
FAU - Alvarez-Vega, P
AU  - Alvarez-Vega P
AD  - Pulmonology Service, Pulmonary Hypertension Unit, Complejo Asistencial 
      Universitario de Salamanca, Salamanca, Spain.
FAU - Martin-Moreiras, J
AU  - Martin-Moreiras J
AD  - Cardiology Service, Pulmonary Hypertension Unit, Complejo Asistencial 
      Universitario de Salamanca, Salamanca, Spain.
FAU - Barreiro-Perez, M
AU  - Barreiro-Perez M
AD  - Cardiology Service, Pulmonary Hypertension Unit, Complejo Asistencial 
      Universitario de Salamanca, Salamanca, Spain.
FAU - Gomez-Sanchez, M A
AU  - Gomez-Sanchez MA
AD  - Cardiology Service, Hospital General Nuestra Senora del Prado, CIBER de 
      Enfermedades Respiratorias (CIBERES), Talavera de la Reina, Spain.
FAU - Sanchez-Fernandez, P L
AU  - Sanchez-Fernandez PL
AD  - Cardiology Service, Pulmonary Hypertension Unit, Complejo Asistencial 
      Universitario de Salamanca, Salamanca, Spain.
LA  - eng
PT  - Journal Article
DEP - 20171122
PL  - Spain
TA  - Pulmonology
JT  - Pulmonology
JID - 101723786
OTO - NOTNLM
OT  - Clinical practice
OT  - Endothelin-receptor antagonist
OT  - Macitentan
OT  - Phosphodiesterase 5 inhibitors
OT  - Prostaglandins
OT  - Pulmonary arterial hypertension
EDAT- 2017/11/28 06:00
MHDA- 2017/11/28 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/07/14 00:00 [received]
PHST- 2017/09/12 00:00 [revised]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2017/11/28 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - S2173-5115(17)30149-5 [pii]
AID - 10.1016/j.rppnen.2017.10.001 [doi]
PST - aheadofprint
SO  - Pulmonology. 2017 Nov 22:S2173-5115(17)30149-5. doi: 
      10.1016/j.rppnen.2017.10.001.