PMID- 29174607
OWN - NLM
STAT- MEDLINE
DCOM- 20191203
LR  - 20191203
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 125
DP  - 2019 Aug
TI  - Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure.
PG  - 397-400
LID - S0034-5288(17)30011-5 [pii]
LID - 10.1016/j.rvsc.2017.09.030 [doi]
AB  - Pulmonary hypertension (PH), remains a challenging disease with a large impact on 
      both humans and meat-type chickens. PH is characterized by the onset of 
      idiopathic pulmonary arterial hypertension leading to right ventricular failure. 
      In this experiment relative gene expression of adenosine A(1) receptor (ADORA1), 
      serotonin transporter (SERT), phosphodiesterase 5A (PDE5) and troponin T2 were 
      compared in hearts from broilers with acute right ventricular failure and from 
      healthy birds. There were major increases in adenosine A(1) receptor (177%) and 
      serotonin transporter (475%), and more modest but significant increases in PDE5 
      (146%) and troponin T2 (140%) gene expressions in broilers with right ventricular 
      failure compared to healthy birds (P<0.01). This novel report shows that 
      pulmonary hypertension related gene expression in broilers is similar to that in 
      humans. This molecular similarity between PH in broilers and human patients 
      suggests, first, that they will make a suitable animal model for study PH in 
      humans, but also that the literature on PH in humans may be profitably applied to 
      the study of PH in broilers.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Kamely, Mohammad
AU  - Kamely M
AD  - Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares 
      University, PO Box 14115-336, Tehran, Iran.
FAU - Karimi Torshizi, Mohammad Amir
AU  - Karimi Torshizi MA
AD  - Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares 
      University, PO Box 14115-336, Tehran, Iran. Electronic address: 
      karimitm@modares.ac.ir.
FAU - Wideman, Robert F
AU  - Wideman RF
AD  - Excellent center of Poultry Science, Arkansas University, Fayetteville, USA.
FAU - West, James
AU  - West J
AD  - Division of Allergy, Pulmonary, and Critical Care Medicine, Department of 
      Medicine, Vanderbilt University Medical Center, Nashville, USA.
LA  - eng
PT  - Journal Article
DEP - 20171005
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Receptor, Adenosine A1)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Troponin T)
RN  - EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5)
SB  - IM
MH  - Animals
MH  - Chickens/*metabolism
MH  - Cyclic Nucleotide Phosphodiesterases, Type 5/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Heart Failure/metabolism/veterinary
MH  - Hypertension, Pulmonary/veterinary
MH  - Male
MH  - Myocardium/metabolism
MH  - Poultry Diseases/metabolism
MH  - Receptor, Adenosine A1/genetics/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*metabolism
MH  - Troponin T/genetics/*metabolism
MH  - *Up-Regulation
OTO - NOTNLM
OT  - Adenosine
OT  - Avian model
OT  - Gene expression
OT  - PDE5
OT  - Pulmonary hypertension
EDAT- 2017/11/28 06:00
MHDA- 2019/12/04 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/01/05 00:00 [received]
PHST- 2017/08/10 00:00 [revised]
PHST- 2017/09/30 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - S0034-5288(17)30011-5 [pii]
AID - 10.1016/j.rvsc.2017.09.030 [doi]
PST - ppublish
SO  - Res Vet Sci. 2019 Aug;125:397-400. doi: 10.1016/j.rvsc.2017.09.030. Epub 2017 Oct 
      5.