PMID- 29174743 OWN - NLM STAT- MEDLINE DCOM- 20180906 LR - 20181202 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 227 DP - 2018 Feb TI - Prefrontal glutamatergic emotion regulation is disturbed in cluster B and C personality disorders - A combined (1)H/(31)P-MR spectroscopic study. PG - 688-697 LID - S0165-0327(17)32133-X [pii] LID - 10.1016/j.jad.2017.10.044 [doi] AB - BACKGROUND: Personality disorders (PD) belong to the most common and most serious mental disorders as regards social dysfunction, inability to work, occurrence of comorbidity and suicidal risk. PDs also crucially influence the incidence, clinical course and treatment response of mental disorders with high suicidal risk, such as depression or substance abuse. One key issue of PD concerns the regulation of emotions. METHODS: Both (1)H-/(31)P-Chemical Shift Imaging (CSI) was applied in a single session to assess neurochemical markers of glutamate function (NAA, Glu) and local energy metabolism (PCr, ATP) in two patient cohorts encompassing 22 cluster B (CB) and 21 cluster C (CC) PD patients, whereby 10 patients of each group were on low-dose antidepressants, and in 60 healthy controls (HC). Non-parametric statistical tests and correlation analyses were performed to assess disease effects on the metabolites and their relation to symptomatology as assessed by SCL-90R self-ratings. RESULTS: Overall comparison including Bonferroni correction revealed significant differences of Glu across all groups in the dorsolateral prefrontal cortex (DLPFC). The following uncorrected results of pairwise tests were obtained: (i) Glu was bilaterally increased in the DLPFC in CB patients, whereas it was - together with NAA - bilaterally decreased in the DLPFC in CC patients and accompanied by increased PCr in the left DLPFC. (ii) NAA and Glu, accompanied by increased PCr, were significantly decreased in the dorsomedial prefrontal cortex (DMPFC) in CC patients. (iii) NAA was decreased in the right anterior cingulate cortex (ACC) in CB patients, and in the left ACC in CC patients with PCr being increased bilaterally. (iv) No associations were observed between metabolites and psychopathology measures. CONCLUSION: The observations in the DLPFC may reflect a neurobiochemical correlate of disturbed cognitive control function in CB and CC PD. While the alterations in CB patients suggest increased basal activity, the observed patterns in CC patients likely reflect decreased or inhibited activity. The alterations of NAA and Glu levels in the ACC and DMPFC indirectly support the assumption of disturbed neuronal function in regions involved in social cognition and mentalizing abilities in both CB and CC PD. Further studies should include the investigation of metabolites of neuronal inhibition (GABA) and the examination of treatment effects. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Smesny, Stefan AU - Smesny S AD - Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. Electronic address: Stefan.Smesny@med.uni-jena.de. FAU - Grosse, Johanna AU - Grosse J AD - Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. FAU - Gussew, Alexander AU - Gussew A AD - Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany. FAU - Langbein, Kerstin AU - Langbein K AD - Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. FAU - Schonfeld, Nils AU - Schonfeld N AD - Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. FAU - Wagner, Gerd AU - Wagner G AD - Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. FAU - Valente, Matias AU - Valente M AD - Department of Psychosomatic Medicine and Psychotherapy, Klinikum am Weissenhof, D-74189 Weinsberg, Germany. FAU - Reichenbach, Jurgen R AU - Reichenbach JR AD - Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171107 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 30KYC7MIAI (Aspartic Acid) RN - 3KX376GY7L (Glutamic Acid) SB - IM MH - Adult MH - Aspartic Acid/metabolism MH - Female MH - Glutamic Acid/*metabolism MH - Gyrus Cinguli/*metabolism MH - Humans MH - Magnetic Resonance Imaging MH - Magnetic Resonance Spectroscopy/methods MH - Male MH - Middle Aged MH - Neurons/metabolism MH - Personality Disorders/*diagnostic imaging/*pathology MH - Prefrontal Cortex/pathology MH - Young Adult OTO - NOTNLM OT - (1)H-MRS OT - (31)P-MRS OT - Biological marker OT - Borderline OT - CSI OT - Emotion regulation OT - Energy metabolism OT - Glutamate OT - Personality disorder EDAT- 2017/11/28 06:00 MHDA- 2018/09/07 06:00 CRDT- 2017/11/28 06:00 PHST- 2017/10/13 00:00 [received] PHST- 2017/10/27 00:00 [accepted] PHST- 2017/11/28 06:00 [pubmed] PHST- 2018/09/07 06:00 [medline] PHST- 2017/11/28 06:00 [entrez] AID - S0165-0327(17)32133-X [pii] AID - 10.1016/j.jad.2017.10.044 [doi] PST - ppublish SO - J Affect Disord. 2018 Feb;227:688-697. doi: 10.1016/j.jad.2017.10.044. Epub 2017 Nov 7.