PMID- 29174968
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 102
DP  - 2018 Feb
TI  - Caloric restriction can improve learning and memory in C57/BL mice probably via 
      regulation of the AMPK signaling pathway.
PG  - 28-35
LID - S0531-5565(17)30492-8 [pii]
LID - 10.1016/j.exger.2017.11.013 [doi]
AB  - Caloric restriction (CR) is effective in slowing aging and delaying aging-related 
      diseases in many species, but the mechanism is complex and not fully elucidated. 
      This study aimed to evaluate the beneficial effects of a caloric restriction diet 
      on learning and memory, and further to elucidate the mechanisms. Thirty-six 
      week-old male C57/BL mice were randomly divided into three groups: normal control 
      (NC group), high-energy (HE group) and CR group. After 44weeks, the Morris water 
      maze was used to examine learning and memory abilities. Western blotting and 
      immunohistochemistry were used to detect changes in proteins involved in the 
      adenosine monophosphate-activated protein kinase (AMPK) pathway in the mouse 
      hippocampus. Compared with NC group, the swimming distance and escape latency 
      were shorter in the CR group. The protein and mRNA expression of AMPK and glucose 
      transporter type 4 (GLUT4) in the CR group were significantly higher than that in 
      HE group. CR increased serum insulin-like growth factor, adiponectin and vaspin, 
      decreased blood glucose and serum malondialdehyde, and improved insulin 
      sensitivity. Our findings demonstrate that a CR diet may improve 
      hippocampus-dependent spatial learning ability of C57/BL mice, accompanied with 
      an increase in AMPK and GLUT4 expression, which indicates AMPK pathway was 
      associated with the neuroprotective effect of CR in mice.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Ma, Lina
AU  - Ma L
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China; Department 
      of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, 
      China.
FAU - Wang, Rong
AU  - Wang R
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China. Electronic 
      address: rong_wang72@aliyun.com.
FAU - Dong, Wen
AU  - Dong W
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.
FAU - Zhao, Zhiwei
AU  - Zhao Z
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171123
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Adipoq protein, mouse)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Serpins)
RN  - 0 (Slc2a4 protein, mouse)
RN  - 0 (Somatomedins)
RN  - 0 (vaspin protein, mouse)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/genetics/*metabolism
MH  - Adipokines/blood
MH  - Adiponectin/blood
MH  - Animal Feed
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - *Behavior, Animal
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - *Caloric Restriction
MH  - Glucose Transporter Type 4/genetics/metabolism
MH  - Hippocampus/*enzymology
MH  - Male
MH  - Malondialdehyde/blood
MH  - *Maze Learning
MH  - *Memory
MH  - Mice, Inbred C57BL
MH  - Serpins/blood
MH  - *Signal Transduction
MH  - Somatomedins/metabolism
MH  - Up-Regulation
OTO - NOTNLM
OT  - AMPK
OT  - Caloric restriction
OT  - Insulin
OT  - Learning
EDAT- 2017/11/28 06:00
MHDA- 2019/01/29 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/06/24 00:00 [received]
PHST- 2017/10/24 00:00 [revised]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - S0531-5565(17)30492-8 [pii]
AID - 10.1016/j.exger.2017.11.013 [doi]
PST - ppublish
SO  - Exp Gerontol. 2018 Feb;102:28-35. doi: 10.1016/j.exger.2017.11.013. Epub 2017 Nov 
      23.