PMID- 29175078 OWN - NLM STAT- MEDLINE DCOM- 20180917 LR - 20181202 IS - 1898-4002 (Electronic) IS - 1896-1126 (Linking) VI - 63 IP - 1 DP - 2018 Mar TI - Limbic brain structures and burnout-A systematic review. PG - 192-198 LID - S1896-1126(17)30075-5 [pii] LID - 10.1016/j.advms.2017.11.004 [doi] AB - More profound understanding of the relationship between the burnout and the limbic system function can provide better insight into brain structures associated with the burnout syndrome. The objective of this review is to explore all evidence of limbic brain structures associated with the burnout syndrome. In total, 13 studies were selected. Four of them applied the neuroimaging technology to investigate the sizes/volumes of the limbic brain structures of burnout patients. Six other studies were to investigate the hypothalamus-pituitary-adrenal (HPA) axis of burnout patients. Based on the results of the studies on the HPA-axis and neuroimaging of the limbic brain structures, one can see great impact of the chronic occupational stress on the limbic structures in terms of HPA dysregulation, a decrease of BDNF, impaired neurogenesis and limbic structures atrophy. It can be concluded that chronic stress inhibits the feedback control pathway in the HPA axis, causes the decrease of brain-derived neurotrophic factor (BDNF), then impaired neurogenesis and eventually neuron atrophy. CI - Copyright (c) 2017 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved. FAU - Chow, YeeKong AU - Chow Y AD - Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, Poland. FAU - Masiak, Jolanta AU - Masiak J AD - Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, Poland. FAU - Mikolajewska, Emilia AU - Mikolajewska E AD - Department of Physiotherapy, Ludwik Rydygier Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Electronic address: e.mikolajewska@wp.pl. FAU - Mikolajewski, Dariusz AU - Mikolajewski D AD - Department of Teleinformatics, Institute of Mechanics and Applied Computer Sciences, Kazimierz Wielki University of Bydgoszcz, Poland; Neurocognitive Laboratory, Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University of Torun, Poland. FAU - Wojcik, Grzegorz Marcin AU - Wojcik GM AD - Department of Neuroinformatics, Institute of Informatics, Maria Curie-Sklodowska University of Lublin, Poland. FAU - Wallace, Brian AU - Wallace B AD - Mater Dei Hospital, Malta. FAU - Eugene, Andy AU - Eugene A AD - Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, USA. FAU - Olajossy, Marcin AU - Olajossy M AD - Department of Psychiatry, Medical University of Lublin, Poland. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20171122 PL - Netherlands TA - Adv Med Sci JT - Advances in medical sciences JID - 101276222 SB - IM MH - Burnout, Professional/*pathology MH - Humans MH - Limbic System/*pathology MH - Neuroimaging OTO - NOTNLM OT - Assessment OT - Brain OT - Burnout OT - Limbic system OT - Work-related stress EDAT- 2017/11/28 06:00 MHDA- 2018/09/18 06:00 CRDT- 2017/11/28 06:00 PHST- 2017/03/24 00:00 [received] PHST- 2017/10/11 00:00 [revised] PHST- 2017/11/13 00:00 [accepted] PHST- 2017/11/28 06:00 [pubmed] PHST- 2018/09/18 06:00 [medline] PHST- 2017/11/28 06:00 [entrez] AID - S1896-1126(17)30075-5 [pii] AID - 10.1016/j.advms.2017.11.004 [doi] PST - ppublish SO - Adv Med Sci. 2018 Mar;63(1):192-198. doi: 10.1016/j.advms.2017.11.004. Epub 2017 Nov 22.