PMID- 29175674 OWN - NLM STAT- MEDLINE DCOM- 20190909 LR - 20190909 IS - 1095-9564 (Electronic) IS - 1074-7427 (Linking) VI - 147 DP - 2018 Jan TI - Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment. PG - 54-64 LID - S1074-7427(17)30198-3 [pii] LID - 10.1016/j.nlm.2017.11.013 [doi] AB - Prenatal morphine exposure causes a variety of neurobehavioral alterations observed in later life. The present study investigated the effects of postnatal exercise and enriched environment (EE) on alterations in water maze learning and hippocampal long-term potentiation (LTP) and brain derived neurotrophic factor (BDNF) levels induced by exposure to morphine during prenatal period in rats. On gestation days 11-18, pregnant rats were injected twice daily with saline or morphine. Offspring were subjected to postnatal exercise and EE for 30 days and afterward, spatial learning and hippocampal LTP and BDNF levels were investigated. Prenatal morphine-exposure impaired the spatial learning and hippocampal LTP in both male and female offspring. Interestingly, postnatal exercise and EE increased performance in the water maze and improved LTP in both prenatally saline and morphine-exposed male and female rats. Prenatal morphine exposure also caused a reduction in the hippocampal BDNF levels in the female, but not male rats, and postnatal exercise and EE alleviated this deficit. Our results demonstrate that postnatal exercise and EE can improve deficits in water maze learning and hippocampal LTP and BDNF levels caused by prenatal morphine exposure. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Ahmadalipour, Ali AU - Ahmadalipour A AD - Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. FAU - Ghodrati-Jaldbakhan, Shahrbanoo AU - Ghodrati-Jaldbakhan S AD - Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran; Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. FAU - Samaei, Seyed Afshin AU - Samaei SA AD - Neuromuscular Rehabilitation Research Center, and Department of Neurology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. FAU - Rashidy-Pour, Ali AU - Rashidy-Pour A AD - Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address: Rashidy-pour@semums.ac.ir. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171123 PL - United States TA - Neurobiol Learn Mem JT - Neurobiology of learning and memory JID - 9508166 RN - 0 (Bdnf protein, rat) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Narcotics) RN - 76I7G6D29C (Morphine) SB - IM MH - Age Factors MH - Animals MH - Behavior, Animal/physiology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - *Environment MH - Female MH - Hippocampus/*metabolism/*physiopathology MH - Long-Term Potentiation/*physiology MH - Male MH - Morphine/*adverse effects MH - Narcotics/*adverse effects MH - Physical Conditioning, Animal/*physiology MH - Pregnancy MH - Prenatal Exposure Delayed Effects/etiology/*physiopathology MH - Random Allocation MH - Rats MH - Rats, Wistar MH - Sex Factors MH - Spatial Learning/*physiology OTO - NOTNLM OT - BDNF OT - Enriched environment OT - Exercise OT - LTP OT - Learning OT - Morphine OT - Prenatal EDAT- 2017/11/28 06:00 MHDA- 2019/09/10 06:00 CRDT- 2017/11/28 06:00 PHST- 2017/04/26 00:00 [received] PHST- 2017/10/26 00:00 [revised] PHST- 2017/11/22 00:00 [accepted] PHST- 2017/11/28 06:00 [pubmed] PHST- 2019/09/10 06:00 [medline] PHST- 2017/11/28 06:00 [entrez] AID - S1074-7427(17)30198-3 [pii] AID - 10.1016/j.nlm.2017.11.013 [doi] PST - ppublish SO - Neurobiol Learn Mem. 2018 Jan;147:54-64. doi: 10.1016/j.nlm.2017.11.013. Epub 2017 Nov 23.