PMID- 29176000
OWN - NLM
STAT- MEDLINE
DCOM- 20180814
LR  - 20181113
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Feb 28
TI  - Effects of GABAB receptor activation on spatial cognitive function and 
      hippocampal neurones in rat models of type 2 diabetes mellitus.
LID - BSR20171184 [pii]
LID - 10.1042/BSR20171184 [doi]
AB  - The present study was conducted with the aim being to investigate the effect 
      gamma-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive 
      function and hippocampal neurones found in the rat models of type 2 diabetes 
      mellitus (T2DM). T2DM rat models were then established, randomized, and 
      subsequently assigned into normal control (NC), T2DM, T2DM + chemical grade 
      propylene (CGP), T2DM + baclofen, and T2DM + CGP + baclofen groups. T2DM rats' 
      weight and blood sugar concentrations were monitored. The DMS-2 Morris water maze 
      testing system was performed in order to figure out the spatial cognitive 
      function of these rats. Reverse-transcription quantitative PCR (RT-qPCR) and 
      Western blotting were also performed in order to detect GABAB mRNA and protein 
      expressions. We used the Nissl staining method in order to detect the number of 
      hippocampal neurones, TUNEL (terminal deoxyribonucleotidy transferase-mediated 
      dUTP nick labeling) staining to detect cell apoptosis, and Western blotting 
      method in order to measure the expressions of the apoptosis-related proteins 
      (Bax, cytochrome c (Cyt-c), Caspase-3, and Bcl-2). In comparison with the T2DM 
      group, the weight decreased, blood sugar concentration increased, and spatial 
      cognitive function as well as hippocampal neurones were both impaired in the T2DM 
      + CGP group, contrary to the rats in the T2DM + baclofen group who showed an 
      opposite trend. The situation in the T2DM + CGP + baclofen group was better than 
      that found in the T2DM + CGP group while proving to be more serious than that of 
      the NC and T2DM + baclofen groups. Conclusively, activating the GABAB receptor 
      improved spatial cognitive function and hippocampal neurones in the T2DM rats.
CI  - (c) 2018 The Author(s).
FAU - Cai, Xiao-Jun
AU  - Cai XJ
AD  - Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150036, P.R. China 
      caixiaojundr@163.com.
FAU - Wang, Lei
AU  - Wang L
AD  - Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150036, P.R. China.
FAU - Hu, Chun-Mei
AU  - Hu CM
AD  - The Third Hospital of Heilongjiang, Beian 164000, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20180119
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Receptors, GABA-B)
RN  - H789N3FKE8 (Baclofen)
SB  - IM
RIN - Biosci Rep. 2020 Mar 27;40(3):. PMID: 32149328
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Baclofen/administration & dosage
MH  - Cognition/*drug effects
MH  - Diabetes Mellitus, Type 2/drug therapy/*genetics/pathology
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Humans
MH  - Maze Learning/drug effects
MH  - Neurons/*drug effects/pathology
MH  - Rats
MH  - Receptors, GABA-B/*genetics
MH  - Signal Transduction/drug effects
MH  - Transcriptional Activation/genetics
PMC - PMC5773821
OTO - NOTNLM
OT  - Gamma-aminobutyric acid type B
OT  - Hippocampal neurons
OT  - Rat models
OT  - Spatial cognitive function
OT  - Type 2 diabetes mellitus
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2017/11/28 06:00
MHDA- 2018/08/15 06:00
PMCR- 2018/01/19
CRDT- 2017/11/28 06:00
PHST- 2017/08/24 00:00 [received]
PHST- 2017/11/17 00:00 [revised]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/08/15 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
PHST- 2018/01/19 00:00 [pmc-release]
AID - BSR20171184 [pii]
AID - 10.1042/BSR20171184 [doi]
PST - epublish
SO  - Biosci Rep. 2018 Jan 19;38(1):BSR20171184. doi: 10.1042/BSR20171184. Print 2018 
      Feb 28.