PMID- 29178009
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 235
IP  - 1
DP  - 2018 Jan
TI  - Gap junction channels as potential targets for the treatment of major depressive 
      disorder.
PG  - 1-12
LID - 10.1007/s00213-017-4782-7 [doi]
AB  - BACKGROUND: Major depressive disorder (MDD) remains a major public health problem 
      worldwide. The association between MDD and the dysfunction of gap junction 
      channels (GJCs) in glial cells, especially astrocytes, is still controversial. 
      OBJECTIVE: This review provides an overview of the role of astrocyte GJCs in 
      LMDD. RESULTS: Exposure to chronic unpredictable stress caused a reduction in 
      connexin expression in the rat prefrontal cortex, a result that is consistent 
      with clinical findings reported in postmortem studies of brains from MDD 
      patients. Chronic antidepressant treatment in these rats increased the expression 
      of connexins. However, pharmacological GJC blockade in normal rodents decreased 
      connexin expression and caused depressive-like behaviors. Furthermore, GJC 
      dysfunction affects electrical conductance, metabolic coupling and secondary 
      messengers, and inflammatory responses, which are consistent with current 
      hypotheses on MDD. All these results provide a comprehensive overview of the 
      neurobiology of MDD. CONCLUSION: This review supports the hypothesis that the 
      regulation of GJCs between astrocytes could be an underlying mechanism for the 
      therapeutic effect of antidepressants.
FAU - Ren, Qian
AU  - Ren Q
AD  - State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, 
      Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, 100050, China.
FAU - Wang, Zhen-Zhen
AU  - Wang ZZ
AD  - State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, 
      Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, 100050, China.
FAU - Chu, Shi-Feng
AU  - Chu SF
AD  - State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, 
      Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, 100050, China.
FAU - Xia, Cong-Yuan
AU  - Xia CY
AD  - State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, 
      Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, 100050, China.
FAU - Chen, Nai-Hong
AU  - Chen NH
AD  - State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, 
      Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, 100050, China. 
      chennh@imm.ac.cn.
AD  - College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 
      410208, China. chennh@imm.ac.cn.
LA  - eng
GR  - 81573636, U1402221, 81560663/National Natural Science Foundation of 
      China/International
GR  - 3332016058/PUMC Youth Fund/International
GR  - 2014RC03, 2016RC350002/Fundamental Research Funds for the Central 
      Universities/International
GR  - 2016-I2M-1-004/CAMS Innovation Fund for Medical Sciences(CIFMS)/International
GR  - 15K091/the Scientific Research Foundation of the Higher Education Institutions of 
      Human Province/International
GR  - BZ0150/Beijing Key Laboratory of New Drug Mechanisms and Pharmacological 
      Evaluation Study/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171125
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Antidepressive Agents)
RN  - 0 (Connexins)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/*therapeutic use
MH  - Connexins/*drug effects
MH  - Depressive Disorder, Major/*drug therapy
MH  - Gap Junctions/*drug effects
MH  - Humans
OTO - NOTNLM
OT  - Antidepressants
OT  - Connexin 43
OT  - Connexin 43 blockers
OT  - Gap junction channels
OT  - Major depressive disorder
EDAT- 2017/11/28 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/04/11 00:00 [received]
PHST- 2017/11/05 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - 10.1007/s00213-017-4782-7 [pii]
AID - 10.1007/s00213-017-4782-7 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2018 Jan;235(1):1-12. doi: 10.1007/s00213-017-4782-7. 
      Epub 2017 Nov 25.