PMID- 29178372
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20181029
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 72
IP  - 3
DP  - 2018 Mar
TI  - THC alters alters morphology of neurons in medial prefrontal cortex, orbital 
      prefrontal cortex, and nucleus accumbens and alters the ability of later 
      experience to promote structural plasticity.
LID - 10.1002/syn.22020 [doi]
AB  - Psychoactive drugs have the ability to alter the morphology of neuronal dendrites 
      and spines and to influence later experience-dependent structural plasticity. If 
      rats are given repeated injections of psychomotor stimulants (amphetamine, 
      cocaine, nicotine) prior to being placed in complex environments, the drug 
      experience interferes with the ability of the environment to increase dendritic 
      arborization and spine density. Repeated exposure to Delta 9-Tetrahydrocannabinol 
      (THC) changes the morphology of dendrites in medial prefrontal cortex (mPFC) and 
      nucleus accumbens (NAcc). To determine if drugs other than psychomotor stimulants 
      will also interfere with later experience-dependent structural plasticity we gave 
      Long-Evans rats THC (0.5 mg/kg) or saline for 11 days before placing them in 
      complex environments or standard laboratory caging for 90 days. Brains were 
      subsequently processed for Golgi-Cox staining and analysis of dendritic 
      morphology and spine density mPFC, orbital frontal cortex (OFC), and NAcc. THC 
      altered both dendritic arborization and spine density in all three regions, and, 
      like psychomotor stimulants, THC influenced the effect of later experience in 
      complex environments to shape the structure of neurons in these three regions. We 
      conclude that THC may therefore contribute to persistent behavioral and cognitive 
      deficits associated with prolonged use of the drug.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Kolb, Bryan
AU  - Kolb B
AUID- ORCID: 0000-0002-2576-0642
AD  - Department of Neuroscience, University of Lethbridge, Alberta, Canada.
AD  - Child Brain Development Program, Canadian Institute for Advanced Research, 
      Toronto, Ontario, Canada.
FAU - Li, Yilin
AU  - Li Y
AD  - Department of Neuroscience, University of Lethbridge, Alberta, Canada.
FAU - Robinson, Terry
AU  - Robinson T
AD  - Department of Psychology, University of Michigan, Ann Arbor, Michigan.
FAU - Parker, Linda A
AU  - Parker LA
AD  - Department of Psychology, University of Guelph, Ontario, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171207
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Psychotropic Drugs)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Cognitive Dysfunction/chemically induced/pathology
MH  - Dronabinol/*pharmacology
MH  - Environment
MH  - Housing, Animal
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Neurons/*drug effects/pathology
MH  - Nucleus Accumbens/*drug effects/pathology
MH  - Prefrontal Cortex/*drug effects/pathology
MH  - Psychotropic Drugs/*pharmacology
MH  - Rats, Long-Evans
OTO - NOTNLM
OT  - D9-THC
OT  - dendrite
OT  - enriched environment
OT  - golgi-cox
OT  - neuroplasticity
OT  - spines
EDAT- 2017/11/28 06:00
MHDA- 2018/10/30 06:00
CRDT- 2017/11/28 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/11/23 00:00 [accepted]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
PHST- 2017/11/28 06:00 [entrez]
AID - 10.1002/syn.22020 [doi]
PST - ppublish
SO  - Synapse. 2018 Mar;72(3). doi: 10.1002/syn.22020. Epub 2017 Dec 7.