PMID- 29178680
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 10
IP  - 1
DP  - 2018 Jan
TI  - T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in 
      Mice.
PG  - 77-82
LID - 10.4168/aair.2018.10.1.77 [doi]
AB  - Eosinophilic inflammation in combination with immunoglobulin E (IgE) production 
      is a characteristic feature of atopic dermatitis. Although activated T-helper 
      type (Th) 2 cells play critical roles in the local accumulation and activation of 
      eosinophils, whether they induce eosinophilic skin inflammation, independent of 
      the IgE-mediated pathway has been unclear. To address the functional role of T 
      cells in allergic skin diseases, we herein transferred Th1/Th2-differentiated or 
      naive DO11.10 T cells into unprimed BALB/c mice. Ovalbumin-specific Th2 cells, as 
      well as eosinophils, accumulated in the skin upon antigen challenge, despite the 
      absence of antigen-specific IgE. Neither antigen-specific Th1 nor naive T cells 
      induced eosinophil accumulation, although Th1 cells by themselves migrated into 
      the skin. Interleukin (IL)-4, IL-5, and eotaxin were specifically produced in the 
      skin of antigen-challenged, Th2 cell-transferred mice, whereas interferon (IFN)-gamma 
      and regulated on activation, normal T cell expressed and secreted (RANTES) were 
      preferentially produced in Th1 cells-transferred mice. Production of monocyte 
      chemoattractant protein (MCP)-1 and MCP-3 was enhanced by both Th1 and Th2 cells. 
      The accumulation of eosinophils and Th2 cells in the skin was suppressed by both 
      dexamethasone and FK506, indicating an essential role of Th2 cells in eosinophil 
      recruitment. We conclude that Th2 cells can induce eosinophilic infiltration into 
      the skin in the absence of antigen-specific IgE.
CI  - Copyright (c) 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Kaminuma, Osamu
AU  - Kaminuma O
AD  - Center for Life Science Research, University of Yamanashi, Yamanashi, Japan.
AD  - Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 
      Tokyo, Japan.
AD  - Clinical Research Center for Allergy and Rheumatology, National Sagamihara 
      Hospital, Kanagawa, Japan.
AD  - RIKEN Bioresource Center, Ibaraki, Japan. osamuk@yamanashi.ac.jp.
FAU - Nishimura, Tomoe
AU  - Nishimura T
AD  - Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 
      Tokyo, Japan.
FAU - Kitamura, Noriko
AU  - Kitamura N
AD  - Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 
      Tokyo, Japan.
FAU - Saeki, Mayumi
AU  - Saeki M
AD  - Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 
      Tokyo, Japan.
AD  - RIKEN Bioresource Center, Ibaraki, Japan.
FAU - Hiroi, Takachika
AU  - Hiroi T
AD  - Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 
      Tokyo, Japan.
FAU - Mori, Akio
AU  - Mori A
AD  - Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 
      Tokyo, Japan.
AD  - Clinical Research Center for Allergy and Rheumatology, National Sagamihara 
      Hospital, Kanagawa, Japan.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC5705487
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - T-lymphocytes
OT  - chemokines
OT  - cytokines
OT  - eosinophils
OT  - immunoglobulin E
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2017/11/28 06:00
MHDA- 2017/11/28 06:01
PMCR- 2018/01/01
CRDT- 2017/11/28 06:00
PHST- 2017/04/04 00:00 [received]
PHST- 2017/07/17 00:00 [revised]
PHST- 2017/08/02 00:00 [accepted]
PHST- 2017/11/28 06:00 [entrez]
PHST- 2017/11/28 06:00 [pubmed]
PHST- 2017/11/28 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.77 [pii]
AID - 10.4168/aair.2018.10.1.77 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2018 Jan;10(1):77-82. doi: 10.4168/aair.2018.10.1.77.