PMID- 29178893 OWN - NLM STAT- MEDLINE DCOM- 20180806 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 19 IP - 1 DP - 2017 Nov 27 TI - 3D whole-heart phase sensitive inversion recovery CMR for simultaneous black-blood late gadolinium enhancement and bright-blood coronary CMR angiography. PG - 94 LID - 10.1186/s12968-017-0405-z [doi] LID - 94 AB - BACKGROUND: Phase sensitive inversion recovery (PSIR) applied to late gadolinium enhancement (LGE) imaging is widely used in clinical practice. However, conventional 2D PSIR LGE sequences provide sub-optimal contrast between scar tissue and blood pool, rendering the detection of subendocardial infarcts and scar segmentation challenging. Furthermore, the acquisition of a low flip angle reference image doubles the acquisition time without providing any additional diagnostic information. The purpose of this study was to develop and test a novel 3D whole-heart PSIR-like framework, named BOOST, enabling simultaneous black-blood LGE assessment and bright-blood visualization of cardiac anatomy. METHODS: The proposed approach alternates the acquisition of a 3D volume preceded by a T(2)-prepared Inversion Recovery (T(2)Prep-IR) module (magnitude image) with the acquisition of a T(2)-prepared 3D volume (reference image). The two volumes (T(2)Prep-IR BOOST and bright-blood T(2)Prep BOOST) are combined in a PSIR-like reconstruction to obtain a complementary 3D black-blood volume for LGE assessment (PSIR BOOST). The black-blood PSIR BOOST and the bright-blood T(2)Prep BOOST datasets were compared to conventional clinical sequences for scar detection and coronary CMR angiography (CMRA) in 18 patients with a spectrum of cardiovascular disease (CVD). RESULTS: Datasets from 12 patients were quantitatively analysed. The black-blood PSIR BOOST dataset provided statistically improved contrast to noise ratio (CNR) between blood and scar when compared to a clinical 2D PSIR sequence (15.8 +/- 3.3 and 4.1 +/- 5.6, respectively). Overall agreement in LGE depiction was found between 3D black-blood PSIR BOOST and clinical 2D PSIR acquisitions, with 11/12 PSIR BOOST datasets considered diagnostic. The bright-blood T(2)Prep BOOST dataset provided high quality depiction of the proximal coronary segments, with improvement of visual score when compared to a clinical CMRA sequence. Acquisition time of BOOST (~10 min), providing information on both LGE uptake and heart anatomy, was comparable to that of a clinical single CMRA sequence. CONCLUSIONS: The feasibility of BOOST for simultaneous black-blood LGE assessment and bright-blood coronary angiography was successfully tested in patients with cardiovascular disease. The framework enables free-breathing multi-contrast whole-heart acquisitions with 100% scan efficiency and predictable scan time. Complementary information on 3D LGE and heart anatomy are obtained reducing examination time. FAU - Ginami, Giulia AU - Ginami G AUID- ORCID: 0000-0003-4669-0572 AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. giulia.ginami@kcl.ac.uk. FAU - Neji, Radhouene AU - Neji R AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. AD - MR Research Collaborations, Siemens Healthcare Limited, Sir William Siemens Square Frimley, Camberley, GU16 8QD, UK. FAU - Rashid, Imran AU - Rashid I AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. FAU - Chiribiri, Amedeo AU - Chiribiri A AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. FAU - Ismail, Tevfik F AU - Ismail TF AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. FAU - Botnar, Rene M AU - Botnar RM AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. AD - Escuela de Ingenieria, Pontificia Universidad Catolica de Chile, Vicuna Mackenna, 4860, Santiago, Chile. FAU - Prieto, Claudia AU - Prieto C AD - School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital (Lambeth Wing), Westminster Bridge Rd, London, SE1 7EH, UK. AD - Escuela de Ingenieria, Pontificia Universidad Catolica de Chile, Vicuna Mackenna, 4860, Santiago, Chile. LA - eng GR - EP/P007619/1/Engineering and Physical Sciences Research Council/ GR - EP/P001009/1/Engineering and Physical Sciences Research Council/ GR - EP/N009258/1/Engineering and Physical Sciences Research Council/ GR - FONDECYT N degrees 1161051/Fondo de Fomento al Desarrollo Cientifico y Tecnologico/ GR - MR/L009676/1/MRC_/Medical Research Council/United Kingdom GR - WT_/Wellcome Trust/United Kingdom GR - MRC MR/L009676/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20171127 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Adult MH - Aged MH - *Cardiac-Gated Imaging Techniques/instrumentation MH - Contrast Media/*administration & dosage MH - Coronary Angiography/instrumentation/*methods MH - Coronary Vessels/*diagnostic imaging/pathology MH - Electrocardiography MH - Feasibility Studies MH - Female MH - Heart Diseases/*diagnostic imaging/pathology MH - Humans MH - *Image Interpretation, Computer-Assisted MH - *Imaging, Three-Dimensional MH - Magnetic Resonance Angiography/instrumentation/*methods MH - Male MH - Middle Aged MH - Myocardium/pathology MH - Organometallic Compounds/*administration & dosage MH - Phantoms, Imaging MH - Predictive Value of Tests MH - Tissue Survival PMC - PMC5702978 OTO - NOTNLM OT - Black-blood OT - Bright-blood OT - Coronary MR angiography OT - Late gadolinium enhancement (LGE) OT - Whole-heart COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study was approved by the National Research Ethics Service and written informed consent was obtained for all the subjects. Anonymized data were analyzed at the School of Biomedical Engineering and Imaging Sciences (King's College London) at the St. Thomas' Hospital. CONSENT FOR PUBLICATION: All the subjects provided written informed consent for the publication of accompanying images in this manuscript. The consent forms are held in the patients' clinical notes and are available to the Editor-in-Chief upon request. COMPETING INTERESTS: R.N. is employed by Siemens Healthcare Limited. All the other Authors declare that they do not have competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2017/11/28 06:00 MHDA- 2018/08/07 06:00 PMCR- 2017/11/27 CRDT- 2017/11/28 06:00 PHST- 2017/08/23 00:00 [received] PHST- 2017/11/06 00:00 [accepted] PHST- 2017/11/28 06:00 [entrez] PHST- 2017/11/28 06:00 [pubmed] PHST- 2018/08/07 06:00 [medline] PHST- 2017/11/27 00:00 [pmc-release] AID - S1097-6647(23)01128-6 [pii] AID - 405 [pii] AID - 10.1186/s12968-017-0405-z [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2017 Nov 27;19(1):94. doi: 10.1186/s12968-017-0405-z.