PMID- 29179650
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 73
IP  - 4
DP  - 2018 Aug
TI  - Statin related adverse effects and patient education: a study from resource 
      limited settings.
PG  - 393-401
LID - 10.1080/00015385.2017.1406884 [doi]
AB  - BACKGROUND: Statins are the most widely prescribed class of drugs for coronary 
      artery disease (CAD) patients and yet literature on the prevalence of statin 
      related adverse effects (AEs) and gaps in patient education is quite limited 
      especially in resource-limited settings of developing world. OBJECTIVES: The 
      present study was conducted to determine the prevalence of myopathy (muscle 
      ailments) and other statin associated adverse effects among CAD patients on 
      statin therapy. The study also aimed to assess patient perceptions, attitudes and 
      awareness concerning the use of statins. METHODS: It was a cross-sectional study 
      conducted among 300 adult CAD patients visiting the out-patient department of a 
      tertiary care hospital in North India, who were receiving statins for their 
      diagnosis. An interviewer administered questionnaire was used to collect data on 
      statin use among patients and adverse effects experienced. RESULTS: Myopathy or 
      muscle related ailments like muscle pain, cramps and muscle weakness were the 
      most prevalent (32, 34 and 47%, respectively), followed by numbness, tingling and 
      burning in the extremities (31%). Joint pain and cognitive impairments were seen 
      in nearly 20% of the patients. The level of awareness among participants 
      regarding the use of statins was sub-optimal. Lack of knowledge and 
      under-reporting of adverse effects were major concerns. CONCLUSION: The study 
      shows that a considerable proportion of statin users experience adverse effects 
      and knowledge and awareness amongst patients is inadequate. Awareness programmes 
      and counselling for patients, sensitisation of healthcare professionals and 
      better screening systems for monitoring AEs can help improve the scenario.
FAU - Mulchandani, Rubina
AU  - Mulchandani R
AD  - a Indian Institute of Public Health-Delhi , Gurgaon , India.
FAU - Lyngdoh, Tanica
AU  - Lyngdoh T
AD  - a Indian Institute of Public Health-Delhi , Gurgaon , India.
FAU - Chakraborty, Praloy
AU  - Chakraborty P
AD  - b Department of Cardiology , Vardhman Mahavir Medical College and Safdarjung 
      Hospital , New Delhi , India.
FAU - Kakkar, Ashish Kumar
AU  - Kakkar AK
AD  - c Department of Pharmacology , Vardhman Mahavir Medical College and Safdarjung 
      Hospital , New Delhi , India.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Artery Disease/*drug therapy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects/therapeutic use
MH  - Incidence
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Myalgia/*chemically induced/epidemiology
MH  - *Patient Compliance
MH  - Patient Education as Topic/*methods
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Statins
OT  - adherence
OT  - adverse effects
OT  - coronary artery disease
OT  - myopathy
OT  - patient education
EDAT- 2017/11/29 06:00
MHDA- 2019/09/04 06:00
CRDT- 2017/11/29 06:00
PHST- 2017/11/29 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2017/11/29 06:00 [entrez]
AID - 10.1080/00015385.2017.1406884 [doi]
PST - ppublish
SO  - Acta Cardiol. 2018 Aug;73(4):393-401. doi: 10.1080/00015385.2017.1406884. Epub 
      2017 Nov 27.