PMID- 29181170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 7
IP  - 5
DP  - 2017 Nov
TI  - Role of Kruppel-like factor 4 and heat shock protein 27 in cancer of the larynx.
PG  - 808-814
LID - 10.3892/mco.2017.1412 [doi]
AB  - Late detection and lack of standard treatment strategies in larynx cancer 
      patients result in high levels of mortality and poor prognosis. Prognostic 
      stratification of larynx cancer patients based on molecular prognostic tumor 
      biomarkers may lead to more efficient clinical management. Kruppel-like factor 4 
      (KLF4) and Heat Shock Protein 27 (HSP27) have an important role in tumorigenesis 
      and are considered promising candidate biomarkers for various types of cancer. 
      However, their role in larynx carcinoma remains to be elucidated. The present 
      study aimed to determine KLF4 and HSP27 expression profiles in laryngeal tumors. 
      The protein and mRNA expression levels of KLF4 and HSP27 were evaluated by 
      immunohistochemical and reverse transcription-polymerase chain reaction analyses 
      in 44 larynx carcinoma samples and 21 normal tissue samples, and then correlated 
      with clinical characteristics. A differential expression of KLF4 and HSP27 was 
      observed between normal and tumor tissues. The protein and mRNA expression levels 
      of KLF4 were significantly decreased in larynx squamous cell carcinoma (LSCC) 
      compared with normal tissue, whereas HSP27 was significantly overexpressed in 
      tumor tissues compared with normal tissues, at the protein and mRNA levels. KLF4 
      expression decreased gradually with tumor progression whereas HSP27 expression 
      increased. A significant difference was observed between stages I and IV. KLF4 
      and HSP27 exhibit opposite functions and roles in the carcinogenic process of 
      LSCC. Their role in laryngeal cancer initiation and progression emphasizes their 
      use as potential future targets for prognosis and treatment. KLF4 and HSP27 
      expression levels may act as potential biomarkers in patients with cancer of the 
      larynx.
FAU - Karam, Jihad
AU  - Karam J
AD  - Anti-Tumor Therapeutic Targeting Laboratory, Faculty of Sciences, Lebanese 
      University, Hadat 1003, Lebanon.
FAU - Fadous-Khalife, Marie Claude
AU  - Fadous-Khalife MC
AD  - Anti-Tumor Therapeutic Targeting Laboratory, Faculty of Sciences, Lebanese 
      University, Hadat 1003, Lebanon.
AD  - Notre Dame de Secours University Hospital, Jbeil 1401, Lebanon.
FAU - Tannous, Rita
AU  - Tannous R
AD  - Anti-Tumor Therapeutic Targeting Laboratory, Faculty of Sciences, Lebanese 
      University, Hadat 1003, Lebanon.
FAU - Fakhreddine, Sally
AU  - Fakhreddine S
AD  - Anti-Tumor Therapeutic Targeting Laboratory, Faculty of Sciences, Lebanese 
      University, Hadat 1003, Lebanon.
FAU - Massoud, Marcel
AU  - Massoud M
AD  - Notre Dame de Secours University Hospital, Jbeil 1401, Lebanon.
FAU - Hadchity, Joseph
AU  - Hadchity J
AD  - Anti-Tumor Therapeutic Targeting Laboratory, Faculty of Sciences, Lebanese 
      University, Hadat 1003, Lebanon.
AD  - Department of Surgery, St. Therese Hospital, Hadat 1003, Lebanon.
FAU - Aftimos, Georges
AU  - Aftimos G
AD  - National Institute of Pathology, Baabda 1003, Lebanon.
FAU - Hadchity, Elie
AU  - Hadchity E
AD  - Anti-Tumor Therapeutic Targeting Laboratory, Faculty of Sciences, Lebanese 
      University, Hadat 1003, Lebanon.
LA  - eng
PT  - Journal Article
DEP - 20170919
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC5700286
OTO - NOTNLM
OT  - HSP27
OT  - KLF4
OT  - RT-PCR
OT  - immunohistochemistry
OT  - larynx cancer
OT  - prognostic markers
EDAT- 2017/11/29 06:00
MHDA- 2017/11/29 06:01
PMCR- 2017/09/19
CRDT- 2017/11/29 06:00
PHST- 2017/02/22 00:00 [received]
PHST- 2017/06/07 00:00 [accepted]
PHST- 2017/11/29 06:00 [entrez]
PHST- 2017/11/29 06:00 [pubmed]
PHST- 2017/11/29 06:01 [medline]
PHST- 2017/09/19 00:00 [pmc-release]
AID - MCO-0-0-1412 [pii]
AID - 10.3892/mco.2017.1412 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2017 Nov;7(5):808-814. doi: 10.3892/mco.2017.1412. Epub 2017 Sep 
      19.