PMID- 29181270
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2160-8407 (Print)
IS  - 2160-8407 (Electronic)
VI  - 7
IP  - 5
DP  - 2017
TI  - Safety and accuracy of (68)Ga-DOTATOC PET/CT in children and young adults with 
      solid tumors.
PG  - 228-235
AB  - (68)Ga-DOTA-tyr3-Octreotide ((68)Ga-DOTATOC) PET/CT has been shown to have high 
      accuracy in adults with neuroendocrine tumors, however has not been studied in 
      pediatric patients. This study evaluated the safety and accuracy of 
      (68)Ga-DOTATOC PET/CT in children and young adults with solid tumors that express 
      somatostatin receptor type 2. A series of three prospective, IRB approved, 
      clinical trials evaluating safety and efficacy of (68)Ga-DOTATOC PET/CT were 
      conducted for subjects aged 6 months to 90 years. This study reports the results 
      for the 26 children and young adults, aged 16 months to 29 years who participated 
      in these trials. The administered activity of (68)Ga-DOTATOC was 1.59 MBq/kg with 
      an upper limit of 111 MBq for subjects < 18 years and 148 MBq for young adults. 
      Safety was assessed with laboratory studies and patient/parent report of symptoms 
      before and after the scan. Scans were interpreted in consensus by two 
      board-certified nuclear medicine physicians. Each scan was categorized on a 
      patient basis as true positive, true negative, false negative or false positive 
      against a reference standard that included a combination of histopathology, other 
      imaging modalities and clinical follow-up. Nine Grade I adverse events (AEs) 
      occurred among 26 subjects, none of which were attributable to (68)Ga-DOTATOC. 
      Sensitivity of (68)Ga-DOTATOC PET/CT was 88% (14 true positive, 2 false negative) 
      and specificity was 100% (10 true negative, 0 false positive). (68)Ga-DOTATOC 
      PET/CT is safe and accurate in children and young adults with solid tumors 
      expressing somatostatin receptor type 2.
FAU - Abongwa, Chenue
AU  - Abongwa C
AD  - Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, 
      University of IowaIowa City, Iowa 52242, USA.
FAU - Mott, Sarah
AU  - Mott S
AD  - Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of 
      Medicine, University of IowaIowa City, Iowa 52242, USA.
FAU - Schafer, Blanca
AU  - Schafer B
AD  - Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, 
      University of IowaIowa City, Iowa 52242, USA.
FAU - McNeely, Parren
AU  - McNeely P
AD  - Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, 
      University of IowaIowa City, Iowa 52242, USA.
FAU - Abusin, Ghada
AU  - Abusin G
AD  - Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, 
      University of IowaIowa City, Iowa 52242, USA.
FAU - O'Dorisio, Thomas
AU  - O'Dorisio T
AD  - Department of Internal Medicine, Roy J. and Lucille A. Carver College of 
      Medicine, University of IowaIowa City, Iowa 52242, USA.
FAU - Zamba, Gideon
AU  - Zamba G
AD  - Department of Biostatistics, College of Public Health, University of IowaIowa 
      City, Iowa 52242, USA.
FAU - O'Dorisio, M Sue
AU  - O'Dorisio MS
AD  - Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, 
      University of IowaIowa City, Iowa 52242, USA.
FAU - Menda, Yusuf
AU  - Menda Y
AD  - Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, 
      University of IowaIowa City, Iowa 52242, USA.
LA  - eng
GR  - P30 CA086862/CA/NCI NIH HHS/United States
GR  - P50 CA174521/CA/NCI NIH HHS/United States
GR  - R01 CA167632/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20171101
PL  - United States
TA  - Am J Nucl Med Mol Imaging
JT  - American journal of nuclear medicine and molecular imaging
JID - 101564121
PMC - PMC5698616
OTO - NOTNLM
OT  - 68Ga-DOTATOC
OT  - children
OT  - solid tumor
OT  - somatostatin
EDAT- 2017/11/29 06:00
MHDA- 2017/11/29 06:01
PMCR- 2017/11/01
CRDT- 2017/11/29 06:00
PHST- 2017/08/02 00:00 [received]
PHST- 2017/10/16 00:00 [accepted]
PHST- 2017/11/29 06:00 [entrez]
PHST- 2017/11/29 06:00 [pubmed]
PHST- 2017/11/29 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Nucl Med Mol Imaging. 2017 Nov 1;7(5):228-235. eCollection 2017.