PMID- 29181621
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 38
IP  - 6
DP  - 2018 Jun
TI  - Monocyte chemoattractant protein-1 as a marker of systemic lupus erythematosus: 
      an observational study.
PG  - 1003-1008
LID - 10.1007/s00296-017-3888-x [doi]
AB  - There is a pivotal need for new markers to be tested in every day clinical 
      practice for systemic lupus erythematosus (SLE) and lupus nephritis (LN). The 
      levels of monocyte chemoattractant protein-1 (MCP-1) in the serum and urine of 72 
      SLE patients (27 with LN and 45 without LN involvement) and 30 healthy 
      individuals were studied to establish their clinical significance. The SLE 
      Disease Activity Index (SLEDAI) was used to establish the disease activity. Urine 
      and serum MCP-1 was determined using the sandwich enzyme immunosorbent assay. 
      Urinary, but not serum MCP-1, positively correlated with proteinuria (r = 0.839; 
      p < 0.001) and negatively correlated with glomerular filtration, evaluated using 
      the modification of diet in renal disease (MDRD) formula (r = - 0.293; p < 0.05), 
      and with C3 complement component in active LN patients (r = - 0.519, p = 0.019). 
      Both serum and urinary MCP-1 demonstrated a positive correlation with SLEDAI 
      (r = 0.318; p < 0.01 and r = 0.431; p < 0.001). We also demonstrated that the 
      levels of serum and urinary MCP-1 were significantly higher in patients with SLE 
      compared to healthy controls, regardless of the disease activity and renal 
      involvement. We recommend MCP-1 measurement in the routine laboratory follow-up 
      of the SLE patients.
FAU - Zivkovic, Valentina
AU  - Zivkovic V
AD  - Faculty of Medicine, University of Nis, Nis, Serbia.
AD  - Institute for Treatment and Rehabilitation, Niska Banja, Nis, Serbia.
FAU - Cvetkovic, Tatjana
AU  - Cvetkovic T
AD  - Faculty of Medicine, University of Nis, Nis, Serbia.
AD  - Clinic of Nephrology Nis, Clinical Centre Nis, Nis, Serbia.
FAU - Mitic, Branka
AU  - Mitic B
AD  - Faculty of Medicine, University of Nis, Nis, Serbia.
AD  - Clinic of Nephrology Nis, Clinical Centre Nis, Nis, Serbia.
FAU - Stamenkovic, Bojana
AU  - Stamenkovic B
AD  - Faculty of Medicine, University of Nis, Nis, Serbia.
AD  - Institute for Treatment and Rehabilitation, Niska Banja, Nis, Serbia.
FAU - Stojanovic, Sonja
AU  - Stojanovic S
AD  - Faculty of Medicine, University of Nis, Nis, Serbia.
AD  - Institute for Treatment and Rehabilitation, Niska Banja, Nis, Serbia.
FAU - Radovanovic-Dinic, Biljana
AU  - Radovanovic-Dinic B
AD  - Faculty of Medicine, University of Nis, Nis, Serbia.
AD  - Clinic of Gastroenterology and Hepatology, Clinical Centre Nis, Nis, Serbia.
FAU - Jurisic, Vladimir
AU  - Jurisic V
AUID- ORCID: 0000-0001-6525-128X
AD  - Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia. 
      vdvd@lycos.com.
LA  - eng
GR  - 175056/Ministarstvo Prosvete, Nauke i Tehnoloskog Razvoja/
PT  - Journal Article
PT  - Observational Study
DEP - 20171127
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Antibodies, Antinuclear
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/*immunology/*metabolism
MH  - Humans
MH  - Lupus Erythematosus, Systemic/blood/*diagnosis
MH  - Lupus Nephritis/blood/*diagnosis
OTO - NOTNLM
OT  - Biomarker
OT  - Lupus nephritis
OT  - Monocyte chemoattractant protein-1 (MPC-1)
OT  - SLEDAI
OT  - Systemic lupus erythematosus
EDAT- 2017/11/29 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/11/29 06:00
PHST- 2017/10/06 00:00 [received]
PHST- 2017/11/19 00:00 [accepted]
PHST- 2017/11/29 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/11/29 06:00 [entrez]
AID - 10.1007/s00296-017-3888-x [pii]
AID - 10.1007/s00296-017-3888-x [doi]
PST - ppublish
SO  - Rheumatol Int. 2018 Jun;38(6):1003-1008. doi: 10.1007/s00296-017-3888-x. Epub 
      2017 Nov 27.