PMID- 29182610
OWN - NLM
STAT- MEDLINE
DCOM- 20180706
LR  - 20240229
IS  - 1689-0035 (Electronic)
IS  - 0065-1400 (Linking)
VI  - 77
IP  - 3
DP  - 2017
TI  - BDNF expression in cat striate cortex is regulated by binocular pattern 
      deprivation.
PG  - 199-204
LID - 10.21307/ane-2017-053 [doi]
AB  - Deprivation of patterned visual information, as in early onset congenital 
      cataract patients, results in a severe impairment in global motion perception. 
      Previously we reported a delayed maturation of the peripheral visual field 
      representation in primary visual area 17, based on a 2-D DIGE screen for protein 
      expression changes and in situ hybridization for the activity reporter gene 
      ZIF268. To corroborate these findings we here explore the binocular pattern 
      deprivation (BD)-regulated expression of brain-derived neurotrophic factor 
      (BDNF), a well-described neurotrophin precipitously regulated by early visual 
      experience. To assess the timing of maturation-related BDNF expression we 
      compared the central and the peripheral visual field representations of area 17 
      of 1, 2, 4 and 6-month-old and adult cats reared under normal visual conditions. 
      To scrutinize the outcome of BD, four different deprivation strategies were 
      compared, including early onset BD from birth and lasting for 2, 4 or 6 months 
      (2BD, 4BD, 6BD), and late onset BD for 2 months upon 2 months of normal vision 
      (2N2BD), as animal models of congenital and delayed onset cataract. During normal 
      cortical development the BDNF transcript levels, measured by quantitative RT-PCR, 
      remained stable. Higher BDNF mRNA levels were found in central area 17 of 2BD and 
      6BD animals compared to age-matched controls. In central area 17, the high BDNF 
      mRNA levels at the end of the BD period may activate a mechanism by which plastic 
      processes, halted by deprivation, may begin. We here confirm that the peripheral 
      visual field representation of area 17 matures slower than its central 
      counterpart. Only in central area 17 normal visual input upon BD could upregulate 
      BDNF mRNA which may lead to a fast activation of local plastic adaptations.
FAU - Laskowska-Macios, Karolina
AU  - Laskowska-Macios K
AD  - Laboratory of Neuroplasticity, Department of Molecular and Cellular Neurobiology, 
      Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, 
      Poland; Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven, Leuven, 
      Belgium.
FAU - Arckens, Lutgarde
AU  - Arckens L
AD  - Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven, Leuven, Belgium.
FAU - Kossut, Malgorzata
AU  - Kossut M
AD  - Laboratory of Neuroplasticity, Department of Molecular and Cellular Neurobiology, 
      Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, 
      Poland; Department of Psychology, SWPS University of Social Sciences and 
      Humanities, Warsaw, Poland.
FAU - Burnat, Kalina
AU  - Burnat K
AD  - Laboratory of Neuroplasticity, Department of Molecular and Cellular Neurobiology, 
      Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, 
      Poland; k.burnat@nencki.gov.pl.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cats
MH  - Early Growth Response Protein 1/genetics/*metabolism
MH  - Gene Expression Regulation/*physiology
MH  - RNA, Messenger/metabolism
MH  - Sensory Deprivation/*physiology
MH  - Visual Cortex/*metabolism
MH  - Visual Fields/physiology
EDAT- 2017/11/29 06:00
MHDA- 2018/07/07 06:00
CRDT- 2017/11/29 06:00
PHST- 2017/11/29 06:00 [entrez]
PHST- 2017/11/29 06:00 [pubmed]
PHST- 2018/07/07 06:00 [medline]
AID - 7723 [pii]
AID - 10.21307/ane-2017-053 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2017;77(3):199-204. doi: 10.21307/ane-2017-053.