PMID- 29183303
OWN - NLM
STAT- MEDLINE
DCOM- 20171214
LR  - 20181113
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Nov 28
TI  - Link between neurodegeneration and trabecular meshwork injury in glaucomatous 
      patients.
PG  - 223
LID - 10.1186/s12886-017-0623-z [doi]
LID - 223
AB  - BACKGROUND: Glaucoma is classified as a neurodegenerative disease. However, the 
      biomarkers of neurodegeneration in the aqueous humour of primary open angle 
      glaucoma (POAG) eyes have not been quantitatively examined yet. In this study, 
      levels of neurodegeneration-related cytokines in the aqueous humour of POAG eyes 
      were measured and compared with those of non-glaucoma (senile cataract) control 
      eyes. METHODS: This cross-sectional study included 24 patients (24 eyes) with 
      POAG and 22 patients (22 eyes) with cataract. Aqueous humour samples were 
      collected before the commencement of phacoemulsification surgery. The 
      concentrations of brain-derived neurotrophic factor (BDNF), cathepsin D, 
      myeloperoxidase (MPO), soluble intercellular adhesion molecule-1 (sICAM-1), 
      soluble neural cell adhesion molecule (sNCAM), soluble vascular cell adhesion 
      molecule-1 (sVCAM-1), and plasminogen activator inhibitor-1 (PAI-1) were measured 
      using the Luminex suspension array technique. The clinical characteristics of the 
      patients were also obtained for correlation analysis. RESULTS: Compared with the 
      cataract group, the levels of cathepsin D (P < 0.001), sNCAM (P < 0.001) and 
      sVCAM-1 (P = 0.007) were significantly higher in the aqueous humour samples from 
      POAG. The levels of BDNF, sICAM-1, MPO and PAI-1 did not differ among the groups. 
      Mean deviation (MD) values measured by the Humphrey Visual Field Analyzer were 
      significantly associated with levels of cathepsin D (P < 0.001; rho= - 0.668), 
      sICAM-1 (P = 0.003; rho= - 0.579), sVCAM-1(P < 0.001; rho= - 0.695), and PAI-1 
      (P = 0.007; rho= - 0.533). The cytokines showed a positive correlation among each 
      other (P < 0.0083). CONCLUSION: These data suggest that POAG patients had 
      elevated levels of multiple biomarkers of neurodegeneration in the aqueous 
      humour, and these elevated biomarkers may be related to trabecular meshwork 
      injury. TRIAL REGISTRATION: This study was registered in the Chinese Clinical 
      Trial Registry ( ChiCTR-OOC-16008516 ) on May 22, 2016.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Department of Ophthalmology, Daping Hospital & Research Institute of Surgery, 
      Third Military Medical University, No.10, Changjiang Branch Road, Chongqing, 
      400042, People's Republic of China.
FAU - Yang, Qinmei
AU  - Yang Q
AD  - Department of Ophthalmology, Daping Hospital & Research Institute of Surgery, 
      Third Military Medical University, No.10, Changjiang Branch Road, Chongqing, 
      400042, People's Republic of China.
FAU - Guo, Feng
AU  - Guo F
AD  - Department of Ophthalmology, Daping Hospital & Research Institute of Surgery, 
      Third Military Medical University, No.10, Changjiang Branch Road, Chongqing, 
      400042, People's Republic of China.
FAU - Chen, Xia
AU  - Chen X
AD  - Department of Ophthalmology, Daping Hospital & Research Institute of Surgery, 
      Third Military Medical University, No.10, Changjiang Branch Road, Chongqing, 
      400042, People's Republic of China.
FAU - Xie, Lin
AU  - Xie L
AD  - Department of Ophthalmology, Daping Hospital & Research Institute of Surgery, 
      Third Military Medical University, No.10, Changjiang Branch Road, Chongqing, 
      400042, People's Republic of China. Xielin1630@163.com.
LA  - eng
PT  - Journal Article
DEP - 20171128
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aqueous Humor/*metabolism
MH  - Biomarkers/metabolism
MH  - Cataract/metabolism
MH  - Cross-Sectional Studies
MH  - Cytokines/*metabolism
MH  - Female
MH  - Glaucoma, Open-Angle/*metabolism/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurodegenerative Diseases/*metabolism
MH  - Trabecular Meshwork/*pathology
PMC - PMC5706159
OTO - NOTNLM
OT  - Aqueous humour
OT  - Cataract
OT  - Neurodegeneration
OT  - Primary open angle glaucoma
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was approved by the 
      Ethical Review Committee of the Daping Hospital of the Third Military Medical 
      University (No._47) and adhered to the provisions of the Declaration of Helsinki 
      for research involving human subjects. We also registered in the Chinese Clinical 
      Trial Registry (ChiCTR-OOC-16008516) on May 22, 2016. Each patient recruited in 
      this study was given an explanation about the research and signed an informed 
      consent for AH collection. CONSENT FOR PUBLICATION: Not applicable. COMPETING 
      INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S 
      NOTE: Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2017/12/01 06:00
MHDA- 2017/12/15 06:00
PMCR- 2017/11/28
CRDT- 2017/11/30 06:00
PHST- 2017/06/26 00:00 [received]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2017/11/30 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2017/12/15 06:00 [medline]
PHST- 2017/11/28 00:00 [pmc-release]
AID - 10.1186/s12886-017-0623-z [pii]
AID - 623 [pii]
AID - 10.1186/s12886-017-0623-z [doi]
PST - epublish
SO  - BMC Ophthalmol. 2017 Nov 28;17(1):223. doi: 10.1186/s12886-017-0623-z.