PMID- 29183706
OWN - NLM
STAT- MEDLINE
DCOM- 20180907
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 66
DP  - 2018 May
TI  - Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the 
      embryonic, postnatal, and adult stages.
PG  - 1-8
LID - S0736-5748(17)30231-9 [pii]
LID - 10.1016/j.ijdevneu.2017.11.004 [doi]
AB  - Dopamine is widely involved in behaviors related to motor activity, cognition, 
      motivation, and reward. Dopamine signal is transduced through the dopamine 
      receptor gene family. The dopamine D1 receptor (D1R) is highly expressed in the 
      striatum, and is responsible for regulating the motor function. Recently, we have 
      reported that the knockdown (KD) mice in which D1R was conditionally eliminated 
      at adult stage, displayed a hypoactivity in the home cage than wild type mice; 
      however, conventional D1R knockout (KO) mice show hyperactive phenotypes. In 
      order to assess whether the difference in the time of eliminating D1R expression 
      affects the behavioral phenotypes, we generated D1R KD mice at the postnatal and 
      adult stages, and compared their motor function with D1R KO mice. Consequently, 
      D1R KD at postnatal and adult stages resulted in severe locomotive defects 
      compared with D1R KO mice. These results suggested that D1R has versatile 
      functions, and the knockdown timing greatly influences the normal motor activity 
      in the adolescent to adult stages.
CI  - Copyright (c) 2017 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Okubo, Tadashi
AU  - Okubo T
AD  - Department of Laboratory Animal Science, Kitasato University School of Medicine, 
      Sagamihara, 252-0374, Japan. Electronic address: okubo@med.kitasato-u.ac.jp.
FAU - Sato, Asako
AU  - Sato A
AD  - Department of Laboratory Animal Science, Kitasato University School of Medicine, 
      Sagamihara, 252-0374, Japan; Department of Anesthesiology, Kitasato University 
      School of Medicine, Sagamihara, 252-0374, Japan.
FAU - Okamoto, Hirotsugu
AU  - Okamoto H
AD  - Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara, 
      252-0374, Japan.
FAU - Sato, Toshiya
AU  - Sato T
AD  - Department of Laboratory Animal Science, Kitasato University School of Medicine, 
      Sagamihara, 252-0374, Japan.
FAU - Sasaoka, Toshikuni
AU  - Sasaoka T
AD  - Department of Laboratory Animal Science, Kitasato University School of Medicine, 
      Sagamihara, 252-0374, Japan; Department of Comparative and Experimental Medicine, 
      Brain Research Institute, Niigata University, Niigata 951-8585, Japan. Electronic 
      address: sasaoka@bri.niigata-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20171126
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Dopamine and cAMP-Regulated Phosphoprotein 32)
RN  - 0 (Receptors, Dopamine D1)
RN  - N12000U13O (Doxycycline)
SB  - IM
MH  - Age Factors
MH  - *Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Bacterial Agents/pharmacology
MH  - Corpus Striatum/embryology/growth & development/metabolism
MH  - Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism
MH  - Doxycycline/pharmacology
MH  - Embryo, Mammalian
MH  - Exploratory Behavior/physiology
MH  - Gene Expression Regulation, Developmental/drug effects/*genetics
MH  - Hyperkinesis/*genetics/physiopathology
MH  - Locomotion/drug effects/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Skills/physiology
MH  - Receptors, Dopamine D1/*deficiency/genetics
OTO - NOTNLM
OT  - Conditional knockdown
OT  - Dopamine D1 receptor
OT  - Motor function
OT  - Postnatal stage
EDAT- 2017/12/01 06:00
MHDA- 2018/09/08 06:00
CRDT- 2017/11/30 06:00
PHST- 2017/08/21 00:00 [received]
PHST- 2017/11/10 00:00 [revised]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2018/09/08 06:00 [medline]
PHST- 2017/11/30 06:00 [entrez]
AID - S0736-5748(17)30231-9 [pii]
AID - 10.1016/j.ijdevneu.2017.11.004 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2018 May;66:1-8. doi: 10.1016/j.ijdevneu.2017.11.004. Epub 
      2017 Nov 26.