PMID- 29184044
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20181202
IS  - 1759-8486 (Electronic)
IS  - 1759-8478 (Linking)
VI  - 10
IP  - 5
DP  - 2018 May
TI  - Intra-arterial oxidative stress correlates negatively with cognitive function and 
      positively with postoperative ischemic lesions in carotid artery stenosis 
      stenting.
PG  - 440-445
LID - 10.1136/neurintsurg-2017-013465 [doi]
AB  - BACKGROUND AND PURPOSE: Carotid plaque contains biologically active substances 
      released into the blood during carotid artery stenting (CAS). The main purpose of 
      this prospective study was to analyse sequential changes in oxidative stress 
      during CAS and their relationship to clinical factors. METHODS: Twenty-two 
      consecutive CAS procedures were performed between May 2014 and April 2016. 
      Arterial blood was collected four times: (1) after the sheath insertion without 
      edaravone; (2) pre-angioplasty with edaravone from the carotid artery; (3) after 
      post-stenting angioplasty from an occluded carotid artery; and (4) before sheath 
      removal. Derivatives of reactive oxygen metabolites (d-ROMs) and biological 
      antioxidant potential (BAP) were measured photometrically. The relationship 
      between d-ROMs or BAP and preoperatively investigated biochemical parameters, 
      cognitive function, and number of diffusion-weighted image (DWI) high spot 
      lesions was analysed using one-way ANOVA and the Tukey-Kramer HSD test. RESULTS: 
      The d-ROM values for CAS were 355+/-58.8 Carratelli Units at sheath insertion, 
      315+/-57.2 after edaravone infusion, 328+/-56.8 after post-stenting angioplasty, and 
      315+/-53.0 just before sheath removal. The d-ROM values were reduced significantly 
      after edaravone infusion (P<0.05). The BAP at sheath insertion was reduced 
      significantly according to age (P<0.05). The d-ROMs at sheath insertion 
      correlated negatively with the dementia scale and positively with the post-CAS 
      DWI high spots (1.00+/-1.07; P<0.05). Other biochemical parameters did not 
      correlate with the d-ROM values or BAP. CONCLUSION: Oxidative stress is 
      correlated negatively with cognitive function and positively with postoperative 
      ischemic lesions. Antioxidant potential decreases with ageing.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Shimamura, Norihito
AU  - Shimamura N
AUID- ORCID: 0000-0003-3003-9160
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Naraoka, Masato
AU  - Naraoka M
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Matsuda, Naoya
AU  - Matsuda N
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Katayama, Kosuke
AU  - Katayama K
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Kakuta, Kiyohide
AU  - Kakuta K
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Katagai, Takeshi
AU  - Katagai T
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Fujiwara, Nozomi
AU  - Fujiwara N
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Fumoto, Toshio
AU  - Fumoto T
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Ohkuma, Hiroki
AU  - Ohkuma H
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20171128
PL  - England
TA  - J Neurointerv Surg
JT  - Journal of neurointerventional surgery
JID - 101517079
RN  - 0 (Antioxidants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angioplasty/adverse effects
MH  - Antioxidants/pharmacology/therapeutic use
MH  - Carotid Stenosis/*metabolism/*surgery
MH  - Cognition Disorders/drug therapy/etiology/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/drug effects/*physiology
MH  - Postoperative Complications/drug therapy/etiology/*metabolism
MH  - Prospective Studies
MH  - Stents/*adverse effects
OTO - NOTNLM
OT  - atherosclerosis
OT  - complication
OT  - intervention
OT  - stent
COIS- Competing interests: None declared.
EDAT- 2017/12/01 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/11/30 06:00
PHST- 2017/09/07 00:00 [received]
PHST- 2017/11/13 00:00 [revised]
PHST- 2017/11/14 00:00 [accepted]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/11/30 06:00 [entrez]
AID - neurintsurg-2017-013465 [pii]
AID - 10.1136/neurintsurg-2017-013465 [doi]
PST - ppublish
SO  - J Neurointerv Surg. 2018 May;10(5):440-445. doi: 10.1136/neurintsurg-2017-013465. 
      Epub 2017 Nov 28.