PMID- 29184346
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0972-2327 (Print)
IS  - 1998-3549 (Electronic)
IS  - 0972-2327 (Linking)
VI  - 20
IP  - 4
DP  - 2017 Oct-Dec
TI  - Cutaneous Adverse Drug Reactions to Lamotrigine and Human Leukocyte Antigen 
      Typing in North Indian Patients: A Case Series.
PG  - 408-410
LID - 10.4103/aian.AIAN_234_17 [doi]
AB  - Cutaneous adverse drug reaction (cADR) has limited epidemiological data in India. 
      The older antiepileptic drugs, i.e., carbamazepine, phenytoin, valproic acid, 
      phenobarbitone, etc., induce severe cADRs that have a strong associated with 
      human leukocyte antigen (HLA)-related genetic risk factors. There is also 
      evidence of association of certain HLA alleles with lamotrigine (LTG)-induced 
      cADRs, but this has not been reported in the Indian population. Here, we report 
      case series of three patients with LTG-induced "Stevens-Johnson syndrome (SJS)." 
      Their HLA-B typing was also performed which showed the presence of HLA-B*15:02 in 
      one case with SJS.
FAU - Srivastava, Shivani
AU  - Srivastava S
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Ramanujam, Bhargavi
AU  - Ramanujam B
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Ihtisham, Kavish
AU  - Ihtisham K
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Tripathi, Manjari
AU  - Tripathi M
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
LA  - eng
PT  - Case Reports
PL  - India
TA  - Ann Indian Acad Neurol
JT  - Annals of Indian Academy of Neurology
JID - 101273955
PMC - PMC5682747
OTO - NOTNLM
OT  - Hypersensitivity
OT  - Stevens-Johnson syndrome
OT  - lamotrigine
OT  - toxic epidermal necrolysis
COIS- There are no conflicts of interest.
EDAT- 2017/12/01 06:00
MHDA- 2017/12/01 06:01
PMCR- 2017/10/01
CRDT- 2017/11/30 06:00
PHST- 2017/11/30 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2017/12/01 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - AIAN-20-408 [pii]
AID - 10.4103/aian.AIAN_234_17 [doi]
PST - ppublish
SO  - Ann Indian Acad Neurol. 2017 Oct-Dec;20(4):408-410. doi: 
      10.4103/aian.AIAN_234_17.