PMID- 29184550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - Natural Killer Cell Interactions with Classical and Non-Classical Human Leukocyte 
      Antigen Class I in HIV-1 Infection.
PG  - 1496
LID - 10.3389/fimmu.2017.01496 [doi]
LID - 1496
AB  - Natural killer (NK) cells are effector lymphocytes of the innate immune system 
      that are able to mount a multifaceted antiviral response within hours following 
      infection. This is achieved through an array of cell surface receptors 
      surveilling host cells for alterations in human leukocyte antigen class I (HLA-I) 
      expression and other ligands as signs of viral infection, malignant 
      transformation, and cellular stress. This interaction between HLA-I ligands and 
      NK-cell receptor is not only important for recognition of diseased cells but also 
      mediates tuning of NK-cell-effector functions. HIV-1 alters the expression of 
      HLA-I ligands on infected cells, rendering them susceptible to NK cell-mediated 
      killing. However, over the past years, various HIV-1 evasion strategies have been 
      discovered to target NK-cell-receptor ligands and allow the virus to escape from 
      NK cell-mediated immunity. While studies have been mainly focusing on the role of 
      polymorphic HLA-A, -B, and -C molecules, less is known about how HIV-1 affects 
      the more conserved, non-classical HLA-I molecules HLA-E, -G, and -F. In this 
      review, we will focus on the recent progress in understanding the role of 
      non-classical HLA-I ligands in NK cell-mediated recognition of HIV-1-infected 
      cells.
FAU - Holzemer, Angelique
AU  - Holzemer A
AD  - First Department of Internal Medicine, University Medical Center 
      Hamburg-Eppendorf, Hamburg, Germany.
AD  - German Center for Infection Research (DZIF), Partner site 
      Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.
FAU - Garcia-Beltran, Wilfredo F
AU  - Garcia-Beltran WF
AD  - Harvard Medical School, Boston, MA, United States.
FAU - Altfeld, Marcus
AU  - Altfeld M
AD  - German Center for Infection Research (DZIF), Partner site 
      Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.
AD  - Institute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, 
      Germany.
LA  - eng
GR  - T32 GM007753/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20171114
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5694438
OTO - NOTNLM
OT  - HIV-1
OT  - human leukocyte antigen class I
OT  - human leukocyte antigen-E
OT  - human leukocyte antigen-F
OT  - innate immunity
OT  - killer cell immunoglobulin-like receptor
OT  - natural killer cells
EDAT- 2017/12/01 06:00
MHDA- 2017/12/01 06:01
PMCR- 2017/01/01
CRDT- 2017/11/30 06:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2017/11/30 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2017/12/01 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.01496 [doi]
PST - epublish
SO  - Front Immunol. 2017 Nov 14;8:1496. doi: 10.3389/fimmu.2017.01496. eCollection 
      2017.