PMID- 2918480
OWN - NLM
STAT- MEDLINE
DCOM- 19890403
LR  - 20151119
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 248
IP  - 2
DP  - 1989 Feb
TI  - Effects of acute and chronic prenatal nicotine treatment on central catecholamine 
      systems of male and female rat fetuses and offspring.
PG  - 786-92
AB  - The effect of acute and chronic prenatal administration of nicotine on central 
      catecholamine systems was studied in Long Evans rats. A single injection of 
      nicotine (1 mg/kg s.c.) to urethane-anesthetized time-pregnant dams at 
      gestational day (GD) 21 increased dopamine, 3,4-dihydroxyphenylacetic acid and 
      homovanillic acid (determined by radioenzymatic assay and high-performance liquid 
      chromatography with electrochemical detection, respectively) in male and female 
      fetal forebrain within 30 min. No significant change was seen in norepinephrine 
      (NE) and MOPEG, but the MOPEG/NE ratio increased in male fetuses. After the 
      administration of nicotine by an osmotic minipump (0.25 mg/kg x hour or vehicle 
      for controls) between GD 12 and 18/19, MOPEG was elevated at GD 18 and reduced at 
      postnatal day (PN) 15 in both sexes; the reduction persisted in males until 
      adulthood (2.5 months). 3,4-dihydroxyphenylacetic acid was affected by chronic 
      drug treatment only in males with an increase at GD 18 and PN 15 and a decrease 
      in adulthood. In contrast, homovanillic acid was reduced in adult offspring of 
      both sexes. Male NE and dopamine of both sexes was above control level at PN 15. 
      Cross-fostering data demonstrate that the changes were due to prenatal 
      influences. The observations indicate that central fetal catecholamine systems 
      are responsive to acute administration of nicotine and that chronic prenatal 
      exposure to the drug results in persistent alterations in the functional state of 
      these neurons. The drug-induced pattern of neurochemical alterations changes 
      during ontogeny until adulthood; it depends upon the sex of the offspring.
FAU - Ribary, U
AU  - Ribary U
AD  - Institute of Pharmacology, University of Zurich, Switzerland.
FAU - Lichtensteiger, W
AU  - Lichtensteiger W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Catecholamines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 6M3C89ZY6R (Nicotine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/analysis
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/*drug effects/metabolism
MH  - Catecholamines/*metabolism
MH  - Female
MH  - Fetus/*drug effects
MH  - Homovanillic Acid/analysis
MH  - Male
MH  - Nicotine/*pharmacology
MH  - Rats
MH  - Sex Factors
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1989 Feb;248(2):786-92.