PMID- 29186723
OWN - NLM
STAT- MEDLINE
DCOM- 20180308
LR  - 20180308
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 59
IP  - 2
DP  - 2018
TI  - Optical Coherence Tomography Angiography in Optic Nerve Drusen.
PG  - 76-80
LID - 10.1159/000481889 [doi]
AB  - AIM: To determine the efficacy of optical coherence tomography angiography 
      (OCT-A) in diagnosing optic nerve head flow impairment in patients with optic 
      nerve drusen. METHODS: Patients affected by optic-nerve head drusen (ONHD) 
      attending the Eye Clinic of the Federico II University of Naples were enrolled in 
      this prospective case series between October 2015 and October 2016. Each patient 
      underwent evaluation of best corrected visual acuity (BCVA), Goldman applanation 
      tonometry, slit-lamp biomicroscopy, fundus examination, standard visual-field 
      testing (perimetry), spectral domain (SD)-OCT and OCT-A. RESULTS: Thirteen 
      patients (6 females and 7 males with a mean age of 22.05 +/- 7.54 years) with ONHD 
      (19 eyes) were enrolled. Mean BCVA was 0.16 +/- 0.21 LogMar and mean intraocular 
      pressure was 15.68 +/- 1.66 mm Hg. The control group constituted 16 individuals (24 
      eyes). Both ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) 
      parameters were lower in patients than in controls. Similarly, the flow index (U 
      = 134, p = 0.021) and vessel density (U = 90, p = 0.001) were significantly lower 
      in eyes affected by ONHD than in normal eyes. Visual-field parameters did not 
      differ between the 2 groups. GCC parameters were significantly correlated with 
      OCT-A parameters (p < 0.05). No correlation was found between RNFL and OCT-A 
      parameters. CONCLUSIONS: Our data suggest that OCT-A could be an objective 
      method, helpful in the analysis of flow changes in patients with ONHD.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Cennamo, Gilda
AU  - Cennamo G
AD  - Eye Clinic, Department of Public Health, Federico II University, Naples, Italy.
FAU - Tebaldi, Sabrina
AU  - Tebaldi S
FAU - Amoroso, Francesca
AU  - Amoroso F
FAU - Arvanitis, Dimitri
AU  - Arvanitis D
FAU - Breve, Mariangelica
AU  - Breve M
FAU - Cennamo, Giovanni
AU  - Cennamo G
LA  - eng
PT  - Journal Article
DEP - 20171130
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Optic Disk/diagnostic imaging/*pathology
MH  - Optic Disk Drusen/diagnostic imaging/*pathology/physiopathology
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Visual Fields
MH  - Young Adult
OTO - NOTNLM
OT  - Ganglion cell complex
OT  - Optic nerve drusen
OT  - Optical coherence tomography angiography
EDAT- 2017/12/01 06:00
MHDA- 2018/03/09 06:00
CRDT- 2017/11/30 06:00
PHST- 2017/07/21 00:00 [received]
PHST- 2017/09/30 00:00 [accepted]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2018/03/09 06:00 [medline]
PHST- 2017/11/30 06:00 [entrez]
AID - 000481889 [pii]
AID - 10.1159/000481889 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2018;59(2):76-80. doi: 10.1159/000481889. Epub 2017 Nov 30.