PMID- 29186896
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 6
IP  - 12
DP  - 2017 Nov 27
TI  - The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial 
      Processing.
LID - 10.3390/jcm6120108 [doi]
LID - 108
AB  - The influence of genes and the environment on the development of Post-Traumatic 
      Stress Disorder (PTSD) continues to motivate neuropsychological research, with 
      one consistent focus being the Brain-Derived Neurotrophic Factor (BDNF) gene, 
      given its impact on the integrity of the hippocampal memory system. Research into 
      human navigation also considers the BDNF gene in relation to hippocampal 
      dependent spatial processing. This speculative paper brings together trauma and 
      spatial processing for the first time and presents exploratory research into 
      their interactions with BDNF. We propose that quantifying the impact of BDNF on 
      trauma and spatial processing is critical and may well explain individual 
      differences in clinical trauma treatment outcomes and in navigation performance. 
      Research has already shown that the BDNF gene influences PTSD severity and 
      prevalence as well as navigation behaviour. However, more data are required to 
      demonstrate the precise hippocampal dependent processing mechanisms behind these 
      influences in different populations and environmental conditions. This paper 
      provides insight from recent studies and calls for further research into the 
      relationship between allocentric processing, trauma processing and BDNF. We argue 
      that research into these neural mechanisms could transform PTSD clinical practice 
      and professional support for individuals in trauma-exposing occupations such as 
      emergency response, law enforcement and the military.
FAU - Miller, Jessica K
AU  - Miller JK
AD  - Faculty of Human, Social & Political Science, University of Cambridge, Cambridge 
      CB2 1TN, UK. jkm35@cam.ac.uk.
FAU - McDougall, Sine
AU  - McDougall S
AD  - Department of Psychology, Bournemouth University, Poole BH12 5BB, UK. 
      smcdougall@bournemouth.ac.uk.
FAU - Thomas, Sarah
AU  - Thomas S
AD  - Faculty of Health & Social Sciences, Clinical Research Unit, Bournemouth 
      University, Poole BH12 5BB, UK. saraht@bournemouth.ac.uk.
FAU - Wiener, Jan
AU  - Wiener J
AD  - Department of Psychology, Ageing and Dementia Research Centre, Bournemouth 
      University, Poole BH12 5BB, UK. jwiener@bournemouth.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC5742797
OTO - NOTNLM
OT  - BDNF
OT  - Brain-Derived Neurotrophic Factor
OT  - PSTD
OT  - Post-Traumatic Stress Disorder
OT  - allocentric
OT  - hippocampus
OT  - navigation
OT  - spatial processing
OT  - trauma
OT  - trauma processing
COIS- The authors declare no conflict of interest. The founding sponsors had no role in 
      the design of the study; in the collection, analyses, or interpretation of data; 
      in the writing of the manuscript, and in the decision to publish the results.
EDAT- 2017/12/01 06:00
MHDA- 2017/12/01 06:01
PMCR- 2017/11/27
CRDT- 2017/12/01 06:00
PHST- 2017/09/15 00:00 [received]
PHST- 2017/10/27 00:00 [revised]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/12/01 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2017/12/01 06:01 [medline]
PHST- 2017/11/27 00:00 [pmc-release]
AID - jcm6120108 [pii]
AID - jcm-06-00108 [pii]
AID - 10.3390/jcm6120108 [doi]
PST - epublish
SO  - J Clin Med. 2017 Nov 27;6(12):108. doi: 10.3390/jcm6120108.