PMID- 29187211
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20190221
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 15
IP  - 1
DP  - 2017 Nov 29
TI  - Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal 
      squamous cell carcinoma.
PG  - 211
LID - 10.1186/s12957-017-1279-0 [doi]
LID - 211
AB  - BACKGROUND: Lymphatic metastasis contributes to the poor prognosis of laryngeal 
      squamous cell carcinoma (LSCC). This study aimed to investigate the roles of two 
      metastasis suppressor genes, KAI1 and nm23, in lymphangiogenesis and lymph 
      metastasis of LSCC. METHODS: A total of 45 LSCC patients were enrolled in this 
      study. The positive expression rates of KAI1 and nm23 protein were detected via 
      immunohistochemistry in 45 LSCC and 22 normal laryngeal mucosa adjacent to LSCC. 
      Micro-lymphatic vessel density (MLVD) was detected via immunohistochemistry with 
      the specific antibody D2-40. Associations between KAI1 and nm23 expression and 
      clinical characteristics of LSCC were then evaluated. RESULTS: The positive 
      expression rates of KAI1 and nm23 were significantly lower in LSCC than normal 
      laryngeal mucosa (P < 0.05). Significantly lower positive rates of KAI1 and nm23 
      were found in LSCC with lymphatic metastasis than those without lymphatic 
      metastasis (P < 0.05), whereas MLVD was negatively correlated with the expression 
      of KAI1 and nm23 (P < 0.05). However, no significant associations were found 
      between KAI1 and nm23 expression and clinical characteristics of LSCC (sex, age, 
      disease position, differentiation, and T-stage). CONCLUSIONS: Both KAI1 and nm23 
      can inhibit lymphangiogenesis and lymphatic metastasis in LSCC.
FAU - Zheng, Zongzhu
AU  - Zheng Z
AD  - Department of Otorhinolaryngology, Taian City Central Hospital, Taian, Shandong, 
      271000, China.
FAU - Tian, Ruihua
AU  - Tian R
AD  - Department of Medical Oncology, Taian City Central Hospital, No. 29 Longtan Road, 
      Taishan District, Taian, Shandong, 271000, China. tianruihua0306@hotmail.com.
FAU - Wang, Ping
AU  - Wang P
AD  - Department of Geriatrics, Taian City Central Hospital, Taian, Shandong, 271000, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171129
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD82 protein, human)
RN  - 0 (Kangai-1 Protein)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - EC 2.7.4.6 (NME1 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Female
MH  - Head and Neck Neoplasms/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Kangai-1 Protein/*metabolism
MH  - Laryngeal Mucosa/pathology
MH  - Laryngeal Neoplasms/*pathology
MH  - *Lymphangiogenesis
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - NM23 Nucleoside Diphosphate Kinases/*metabolism
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
PMC - PMC5707808
OTO - NOTNLM
OT  - KAI1
OT  - Laryngeal squamous cell carcinoma
OT  - Lymphangiogenesis
OT  - Lymphatic metastasis
OT  - nm23
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was approved by the local 
      Institutional Review Board, and informed consent was obtained from all subjects. 
      CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare 
      that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains 
      neutral with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2017/12/01 06:00
MHDA- 2018/07/28 06:00
PMCR- 2017/11/29
CRDT- 2017/12/01 06:00
PHST- 2017/02/17 00:00 [received]
PHST- 2017/11/15 00:00 [accepted]
PHST- 2017/12/01 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/11/29 00:00 [pmc-release]
AID - 10.1186/s12957-017-1279-0 [pii]
AID - 1279 [pii]
AID - 10.1186/s12957-017-1279-0 [doi]
PST - epublish
SO  - World J Surg Oncol. 2017 Nov 29;15(1):211. doi: 10.1186/s12957-017-1279-0.