PMID- 29187293
OWN - NLM
STAT- MEDLINE
DCOM- 20190822
LR  - 20210521
IS  - 2529-993X (Electronic)
IS  - 2529-993X (Linking)
VI  - 36
IP  - 10
DP  - 2018 Dec
TI  - Immune reconstitution inflammatory syndrome in HIV-infected patients with 
      Pneumocystis jirovecii pneumonia.
PG  - 621-626
LID - S0213-005X(17)30327-0 [pii]
LID - 10.1016/j.eimc.2017.11.002 [doi]
AB  - INTRODUCTION: The incidence of immune reconstitution inflammatory syndrome (IRIS) 
      in HIV-infected patients after an episode of Pneumocystis jirovecii pneumonia 
      (PJP) seems to be lower than with other opportunistic infections. We conducted an 
      observational study in order to determine the incidence, clinical characteristics 
      and outcome of patients diagnosed with PJP-related IRIS. METHODS: We conducted an 
      observational study of HIV patients diagnosed with PJP-related IRIS from January 
      2000 to November 2015. We analyzed epidemiological and clinical characteristics 
      as well as laboratory findings. We also carried out a systematic review of 
      published cases. RESULTS: Six cases of IRIS out of 123 (4.9%) HIV-infected 
      patients with PJP who started ART were diagnosed. All six cases were men with a 
      median age of 34 (IQR: 8) years. The six patients developed paradoxical IRIS. 
      Subjects younger than 40 years old (p=0.084) and with an HIV-RNA viral load 
      >100000 copies/ml (p=0.081) at diagnosis showed a tendency to develop IRIS. 
      Thirty-seven published cases of PJP-related IRIS were identified. Although 51% of 
      cases involved respiratory failure, no deaths were reported. CONCLUSIONS: 
      PJP-related IRIS is rare condition compared to other opportunistic infections. It 
      can lead to a severe respiratory failure in a significant proportion of cases, 
      although no deaths have been reported.
CI  - Copyright (c) 2017 Elsevier Espana, S.L.U. and Sociedad Espanola de Enfermedades 
      Infecciosas y Microbiologia Clinica. All rights reserved.
FAU - Roade Tato, Luisa
AU  - Roade Tato L
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain. Electronic address: 
      luisaroadet@gmail.com.
FAU - Burgos Cibrian, Joaquin
AU  - Burgos Cibrian J
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Curran Fabregas, Adria
AU  - Curran Fabregas A
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Navarro Mercade, Jordi
AU  - Navarro Mercade J
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Willekens, Rein
AU  - Willekens R
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Martin Gomez, Maria Teresa
AU  - Martin Gomez MT
AD  - Microbiology Department, University Hospital Vall d'Hebron, Universitat Autonoma 
      de Barcelona, Barcelona, Spain.
FAU - Ribera Pascuet, Esteban
AU  - Ribera Pascuet E
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Falco Ferrer, Vicenc
AU  - Falco Ferrer V
AD  - Infectious Diseases Department, University Hospital Vall d'Hebron, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Observational Study
DEP - 20171126
PL  - Spain
TA  - Enferm Infecc Microbiol Clin (Engl Ed)
JT  - Enfermedades infecciosas y microbiologia clinica (English ed.)
JID - 101777541
MH  - Adult
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/diagnosis/epidemiology/*microbiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Pneumocystis carinii
MH  - Pneumonia, Pneumocystis/*complications
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Human immunodeficiency virus
OT  - Immune reconstitution
OT  - Pneumocystis jirovecii
OT  - Reconstitucion inmune
OT  - Virus de la inmunodeficiencia humana
EDAT- 2017/12/01 06:00
MHDA- 2019/08/23 06:00
CRDT- 2017/12/01 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/11/01 00:00 [accepted]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2019/08/23 06:00 [medline]
PHST- 2017/12/01 06:00 [entrez]
AID - S0213-005X(17)30327-0 [pii]
AID - 10.1016/j.eimc.2017.11.002 [doi]
PST - ppublish
SO  - Enferm Infecc Microbiol Clin (Engl Ed). 2018 Dec;36(10):621-626. doi: 
      10.1016/j.eimc.2017.11.002. Epub 2017 Nov 26.