PMID- 29187487
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20171211
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 12
DP  - 2017 Dec
TI  - Stereotactic Body Radiation Therapy in Primary and Metastatic Liver Disease.
PG  - 7005-7010
AB  - BACKGROUND/AIM: The aim of this study was to investigate the treatment outcomes 
      and toxicities in patients with liver disease treated by Stereotactic Body 
      Radiation Therapy (SBRT). PATIENTS AND METHODS: From 2007 to 2016, 43 patients 
      with 58 lesions (6 primary and 37 metastatic liver tumors) were treated with 
      SBRT. RESULTS: Local Control was reached in 47 out of 58 (81%) treated lesions 
      with 12 and 24-month rates of 81% and 74% respectively. The progression-free 
      survival at 12 and 24 months was 42% and 36%, respectively. The disease specific 
      survival at 12 and 24 months was 74% and 46% respectively. Median overall 
      survival (OS) was 20 months and the rates of OS were 74% and 46% at 12 and 24 
      months respectively. Toxicity was very low consisting mainly of Grade 1 and 2. 
      CONCLUSION: SBRT provides good local control for both primary and metastatic 
      liver lesions, with minimal toxicity.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Caivano, Donatella
AU  - Caivano D
AD  - CNAO, National Centre of Oncological Hadrontherapy, Pavia, Italy 
      donatella.caivano@gmail.com.
FAU - Valeriani, Maurizio
AU  - Valeriani M
AD  - Department of Radiation Oncology, University of Rome "Sapienza", Faculty of 
      "Medicina e Psicologia", Sant'Andrea Hospital, Rome, Italy.
FAU - Russo, Ivana
AU  - Russo I
AD  - Department of Radiation Oncology, University of Rome "Sapienza", Faculty of 
      "Medicina e Psicologia", Sant'Andrea Hospital, Rome, Italy.
FAU - Bonome, Paolo
AU  - Bonome P
AD  - Department of Radiation Oncology, University of Rome "Sapienza", Faculty of 
      "Medicina e Psicologia", Sant'Andrea Hospital, Rome, Italy.
FAU - DE Matteis, Sara
AU  - DE Matteis S
AD  - Department of Radiation Oncology, University of Rome "Sapienza", Faculty of 
      "Medicina e Psicologia", Sant'Andrea Hospital, Rome, Italy.
FAU - Minniti, Giuseppe
AU  - Minniti G
AD  - Neuromed - Mediterranean Neurological Institute, Pozzilli, Italy.
FAU - Osti, Mattia Falchetto
AU  - Osti MF
AD  - Department of Radiation Oncology, University of Rome "Sapienza", Faculty of 
      "Medicina e Psicologia", Sant'Andrea Hospital, Rome, Italy.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Abdominal Pain/etiology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diarrhea/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Liver Neoplasms/*pathology/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Nausea/etiology
MH  - Neoplasm Metastasis
MH  - Radiosurgery/adverse effects/*methods
MH  - *Radiotherapy Dosage
MH  - Treatment Outcome
OTO - NOTNLM
OT  - SBRT
OT  - local control
OT  - outcomes of survival
OT  - toxicities
OT  - univariate analysis
EDAT- 2017/12/01 06:00
MHDA- 2017/12/12 06:00
CRDT- 2017/12/01 06:00
PHST- 2017/09/14 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/10/19 00:00 [accepted]
PHST- 2017/12/01 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
AID - 37/12/7005 [pii]
AID - 10.21873/anticanres.12169 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Dec;37(12):7005-7010. doi: 10.21873/anticanres.12169.