PMID- 29188597 OWN - NLM STAT- MEDLINE DCOM- 20181113 LR - 20181113 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 25 IP - 5 DP - 2018 Feb TI - Association of urinary concentrations of four chlorophenol pesticides with cardiometabolic risk factors and obesity in children and adolescents. PG - 4516-4523 LID - 10.1007/s11356-017-0771-y [doi] AB - This study was undertaken to determine the association of four chlorophenol pesticides with cardiometabolic risk factors and obesity in children and adolescents. This cross-sectional study was conducted in 2016 on 242 children and adolescents, aged 6 to 18 years. The concentrations of 2,4-dichlorophenol (2,4-DCP), 2,5-dichlorophenol (2,5-DCP), 2,4,5-trichlorophenol (2,4,5-TCP), and 2,4,6-trichlorophenol (2,4,6-TCP) in the urine were examined and their association with indices of obesity and cardiometabolic risk factors was determined. Multivariate linear regression and multinomial logistic regression analyses were applied. Overall, 242 participants with mean (SD) ages of 11.3 (2.5) years completed the survey. After adjustment for confounders, a significant positive association was found between body mass index (BMI) z-score and waist circumference (WC) with 2,5-DCP (0.07 (95% CI 0.04, 0.1)) and 0.79 (95% CI 0.54, 1.03), respectively. A significant association of 2,4,5-TCP was only found with WC (0.23 (95% CI 0.0, 0.46), but the relationship with 2,4-DCP was not significant. 2,5-DCP had a significant relationship only with obesity (1.09 (95% CI 1.1, 1.19)), while 2,4-DCP and 2,4,5-TCP showed no significant correlation with overweight or obesity. 2,4-DCP showed a significant positive relationship with high density lipoprotein-cholesterol (HDL-C). Moreover, 2,5-DCP showed a significant negative relationship only with systolic blood pressure and 2,4,5-TCP had a statistically significant inverse association with total cholesterol and HDL-C (-0.71 (95% CI -0.98, -0.45)). This study suggests potential associations of chlorophenol pesticides with overweight, obesity, lipid profile, and blood pressure in children and adolescents. Longitudinal studies are necessary to assess the clinical impact of these findings. FAU - Parastar, Saeed AU - Parastar S AD - Environment Research Center, Research Institute for Primordial Prevention of Non communicable disease, Isfahan University of Medical Sciences, P.O. Box 81746-73461, Isfahan, Iran. AD - Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Ebrahimpour, Karim AU - Ebrahimpour K AD - Environment Research Center, Research Institute for Primordial Prevention of Non communicable disease, Isfahan University of Medical Sciences, P.O. Box 81746-73461, Isfahan, Iran. AD - Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Hashemi, Majid AU - Hashemi M AD - Environment Research Center, Research Institute for Primordial Prevention of Non communicable disease, Isfahan University of Medical Sciences, P.O. Box 81746-73461, Isfahan, Iran. AD - Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Maracy, Mohammad Reza AU - Maracy MR AD - Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Ebrahimi, Afshin AU - Ebrahimi A AUID- ORCID: 0000-0002-3640-087X AD - Environment Research Center, Research Institute for Primordial Prevention of Non communicable disease, Isfahan University of Medical Sciences, P.O. Box 81746-73461, Isfahan, Iran. a_ebrahimi@hlth.mui.ac.ir. AD - Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. a_ebrahimi@hlth.mui.ac.ir. FAU - Poursafa, Parinaz AU - Poursafa P AD - Environment Research Center, Research Institute for Primordial Prevention of Non communicable disease, Isfahan University of Medical Sciences, P.O. Box 81746-73461, Isfahan, Iran. FAU - Kelishadi, Roya AU - Kelishadi R AD - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20171129 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Chlorophenols) RN - 0 (Pesticides) SB - IM MH - Adolescent MH - Blood Pressure/drug effects MH - Cardiovascular Diseases/*etiology/urine MH - Child MH - Chlorophenols/toxicity/*urine MH - Cross-Sectional Studies MH - Environmental Exposure/adverse effects/*analysis MH - Female MH - Humans MH - Iran MH - Linear Models MH - Lipid Metabolism/drug effects MH - Male MH - Metabolic Diseases/*etiology/urine MH - Pediatric Obesity/complications/*urine MH - Pesticides/toxicity/*urine MH - Risk Factors OTO - NOTNLM OT - Blood pressure OT - Children OT - Lipid profile OT - Obesity OT - Pesticides OT - Urinary chlorophenols EDAT- 2017/12/01 06:00 MHDA- 2018/11/14 06:00 CRDT- 2017/12/01 06:00 PHST- 2017/07/07 00:00 [received] PHST- 2017/11/15 00:00 [accepted] PHST- 2017/12/01 06:00 [pubmed] PHST- 2018/11/14 06:00 [medline] PHST- 2017/12/01 06:00 [entrez] AID - 10.1007/s11356-017-0771-y [pii] AID - 10.1007/s11356-017-0771-y [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2018 Feb;25(5):4516-4523. doi: 10.1007/s11356-017-0771-y. Epub 2017 Nov 29.